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AB188155

Anti-SERPINE3 antibody

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(1 Publication)

Rabbit Polyclonal SERPINE3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SERPINE3 aa 300-450.

View Alternative Names

Serpin E3, SERPINE3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SERPINE3 antibody (AB188155)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SERPINE3 antibody (AB188155)

Immunohistochemical analysis of paraffin-embedded Human colon tissue, labeling SERPINE3 using ab188155 at a 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SERPINE3 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.

A8MV23

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SERPINE3 also known as serpin family E member 3 functions as a serine protease inhibitor. It has a molecular mass of approximately 45 kDa. This protein inhibits its target proteases by forming a stable complex preventing them from interacting with their substrates. The expression of SERPINE3 is observed primarily in the liver and also noted in other tissues such as the pancreas and kidney indicating its role in various physiological processes across different body systems.
Biological function summary

The main function of SERPINE3 involves the regulation of protease activity which is critical for maintaining tissue homeostasis and preventing excessive proteolysis. Serine protease inhibitors like SERPINE3 can be part of larger protein complexes that finely tune proteolytic cascades by binding to specific active serine proteases. This regulatory mechanism helps control processes such as coagulation fibrinolysis and immune response where balance is key for proper function.

Pathways

SERPINE3 plays roles in both the coagulation and the fibrinolytic pathways serving as an important regulator in blood clotting and clot breakdown. In these pathways SERPINE3 interacts with other proteins including plasminogen and plasmin to either facilitate or impede clot dissolution. Such interactions help maintain a balance between clot formation and breakdown ensuring that bleeding is controlled while preventing excessive clotting which could lead to conditions such as thrombosis.

Disturbances in SERPINE3 function have been associated with certain cardiovascular disorders particularly those that involve abnormal blood clotting like thrombosis. Aberrant regulation of protease activity related to SERPINE3 can also link to cancer progression as the balance between proteolytic activity and inhibition affects tumor invasion and metastasis. Dysregulation of SERPINE3 might also affect proteins involved in these disorders such as tissue plasminogen activator (tPA) which plays a significant role in clot breakdown. Proper understanding of SERPINE3 involvement helps in exploring therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable serine protease inhibitor.
See full target information SERPINE3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

RSC advances 8:10706-10714 PubMed35540477

2018

MiR-19b alleviates MPP-induced neuronal cytotoxicity targeting the HAPLN4/MAPK pathway in SH-SY5Y cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Lijiao Geng,Yong Chen
View all publications
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Product promise

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