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AB69236

Anti-Serratia marcescens antibody [B/N4N]

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(1 Publication)

Mouse Monoclonal Serratia marcescens antibody. Suitable for ELISA, ICC/IF and reacts with Serratia marcescens samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Serratia marcescens protein.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B/N4N

Isotype

IgG1

Carrier free

No

Reacts with

Serratia marcescens

Applications

ICC/IF, ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Serratia marcescens": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.065% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Serratia marcescens is a Gram-negative bacterium that often exists in water soil and as a part of the human microbiota. Known commonly for its reddish pigment prodigiosin this bacterium exhibits a variety of mechanical actions including quorum sensing secretion of virulence factors and motility. These actions involve a combination of surface-expressed proteins and enzymes. With a mass particular to its structure S. marcescens demonstrates flexibility in occupying diverse environments including hospital settings where it can become opportunistic.
Biological function summary

Serratia marcescens plays a role in infection processes due to its secretion of extracellular enzymes such as proteases lipases and DNases enhancing its pathogenic capabilities. The bacterium is part of biofilm-forming complexes that contribute to its resilience against environmental stress. This ability to form biofilms increases its persistence in medical devices and surfaces complicating treatment of infections it causes.

Pathways

Serratia marcescens participates in mechanisms that involve quorum sensing networks particularly through the SmaI/SmaR system akin to LuxI/LuxR systems found in other bacteria. This involves the synthesis and detection of signaling molecules regulating gene expression related to virulence and biofilm formation. The bacterium links to other bacterial proteins that modulate these pathways facilitating communication and coordination among microbial communities.

Serratia marcescens is associated with opportunistic infections such as urinary tract infections and pneumonia often in immunocompromised individuals. The bacterium's interaction with host proteins like mannose-binding lectin can influence its pathogenicity. Its ability to produce multiple antibiotic resistance through chromosomal mutations further complicates treatment making S. marcescens a challenging target in clinical microbiology.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:1242 PubMed32144270

2020

CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Joon-Il Jun,Lester F Lau
View all publications

Product promise

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