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AB190801

Anti-Serum Amyloid A antibody [EPR11592-129]

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(1 Publication)

Rabbit Recombinant Monoclonal Serum Amyloid A 1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Serum amyloid A-1 protein, SAA, SAA1

2 Images
Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (AB190801)
  • WB

Supplier Data

Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (AB190801)

All lanes:

Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (ab190801) at 1/1000 dilution

Lane 1:

Human serum lysate at 10 µg

Lane 2:

Human plasma lysate at 10 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 14 kDa

Observed band size: 12 kDa

false

Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (AB190801)
  • WB

Supplier Data

Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (AB190801)

All lanes:

Western blot - Anti-Serum Amyloid A antibody [EPR11592-129] (ab190801) at 1/5000 dilution

All lanes:

Human Serum Amyloid A2 recombinant protein (UniProt P0DJI9) with proprietary tag at 0.01 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 14 kDa

Observed band size: 38 kDa

false

  • Carrier free

    Anti-Serum Amyloid A antibody [EPR11592-129] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11592-129

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Serum Amyloid A (SAA) is an important acute-phase protein with a mass of approximately 12 kDa. It plays a role in inflammation and is present in the serum. SAA is an apolipoprotein that associates with high-density lipoprotein (HDL) during inflammatory states. The protein is expressed mainly in the liver and circulating SAA levels greatly increase during inflammatory responses marking it as an important marker for inflammation.
Biological function summary

SAA contributes to the body's immune response to injury by recruiting immune cells and facilitating the removal of cholesterol. As part of the acute-phase response SAA integrates into HDL displacing other apolipoproteins and altering HDL's function. Increased SAA levels can also modulate prostaglandin synthesis and secretion influencing the inflammatory response. The exact role of SAA in pathways beyond these functions continues to be a subject of research.

Pathways

SAA influences lipid metabolism and inflammatory pathways. It plays a significant role within the acute-phase response pathway which modulates the immune system’s reaction to stress such as infection or injury. Another pathway involves cholesterol metabolism where SAA interacts with apolipoproteins AI and AII altering the composition and function of HDL particles.

High levels of SAA associate with amyloidosis and chronic inflammatory diseases. In amyloidosis misfolded SAA proteins deposit as amyloid fibrils in tissues leading to organ dysfunction. In dogs and other species SAA is used as a biomarker to monitor inflammatory diseases. Its connection with C-reactive protein further emphasizes its role in inflammatory processes. Research continues to explore how modulating SAA levels may impact disease progression and treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Major acute phase protein.
See full target information SAA1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Arthritis & rheumatology (Hoboken, N.J.) 69:1832-1839 PubMed28544690

2017

Brief Report: Deficiency of Complement 1r Subcomponent in Early-Onset Systemic Lupus Erythematosus: The Role of Disease-Modifying Alleles in a Monogenic Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Erkan Demirkaya,Qing Zhou,Carolyne K Smith,Michael J Ombrello,Natalie Deuitch,Wanxia L Tsai,Patrycja Hoffmann,Elaine F Remmers,Masaki Takeuchi,Yong Hwan Park,JaeJin Chae,Kenan Barut,Dogan Simsek,Amra Adrovic,Sezgin Sahin,Salim Caliskan,Settara C Chandrasekharappa,Sarfaraz A Hasni,Amanda K Ombrello,Massimo Gadina,Daniel L Kastner,Mariana J Kaplan,Ozgur Kasapcopur,Ivona Aksentijevich
View all publications
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Product promise

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