AB235789

Anti-Seryl-tRNA synthetase/SERS antibody

Name: Anti-Seryl-tRNA synthetase/SERS antibody (ab235789) | Abcam
Brand: Abcam Limited
SKU: AB235789
Price: 525 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal Seryl-tRNA synthetase/SERS antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SARS1 aa 1-250.

View Alternative Names

SARS, SERS, SARS1, Seryl-tRNA synthetase, Seryl-tRNA(Ser/Sec) synthetase, SerRS

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

Paraffin-embedded human placenta tissue stained for Seryl-tRNA synthetase/SERS using ab235789 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

Paraffin-embedded human melanoma tissue stained for Seryl-tRNA synthetase/SERS using ab235789 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

All lanes:

Western blot - Anti-Seryl-tRNA synthetase/SERS antibody (ab235789) at 1/1000 dilution

Lane 1:

EC109 whole cell lysate

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/15000 dilution

Predicted band size: 59 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SARS1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

P49591

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Seryl-tRNA synthetase also known as SERS is an enzyme responsible for catalyzing the attachment of serine to its corresponding tRNA molecule a process known as aminoacylation. SERS with a molecular mass of approximately 55 kDa finds its expression in various tissues and cell types where it plays a role in protein synthesis. It operates by ensuring that genetic information is translated accurately from nucleic acid sequences to protein sequences important in maintaining the fidelity of protein biosynthesis.

Biological function summary

Through its function of aminoacylating serine to tRNA SERS contributes to the synthesis of proteins by enabling the incorporation of serine residues into polypeptides. SERS does not act alone; instead it operates as a part of the multi-tRNA synthetase complex enhancing its enzymatic efficiency and aiding in the coordination of protein synthesis. Beyond catalysis SERS also participates in cellular response to stress and has non-canonical roles that extend its function beyond tRNA charging.

Pathways

The role of SERS in translation aligns it with pathways involving protein synthesis and amino acid metabolism. One such pathway is the mTOR signaling pathway which SERS influences indirectly through its role in the availability of serine-loaded tRNAs for protein synthesis. Additionally SERS is linked to serine biosynthesis pathways interconnected with proteins like PHGDH which catalyzes the first step in the serine biosynthesis from 3-phosphoglycerate.

The malfunction or aberrant expression of SERS associates with Charcot-Marie-Tooth disease a neuropathy affecting peripheral nerves. Mutations in SERS can disrupt normal nerve function leading to symptoms associated with this disorder. Furthermore SERS links to cancerous processes as its non-canonical functions may influence tumor progression. In cancer SERS interacts with proteins such as oncogenes or tumor suppressors affecting cellular proliferation and survival.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction : serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed : 22353712, PubMed : 24095058, PubMed : 26433229, PubMed : 28236339, PubMed : 34570399, PubMed : 36041817, PubMed : 9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed : 26433229, PubMed : 28236339, PubMed : 34570399, PubMed : 9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed : 24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed : 19423847, PubMed : 19423848, PubMed : 24940000).

See full target information SARS1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 25:109 PubMed40119335

2025

TMEM71 is crucial for cell proliferation in lower-grade glioma and is linked to unfavorable prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiabao Xie,Wanli Yu,Shikai Gui,Lunshan Peng,Juexian Xiao,Haitao Luo,Zujue Cheng

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Seryl-tRNA synthetase/SERS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

Western blot - Anti-Seryl-tRNA synthetase/SERS antibody (AB235789)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise