Rabbit Recombinant Monoclonal SETBP1 antibody. Suitable for IHC-P and reacts with Human samples.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img58099.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137694.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137109.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img131063.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img118441.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (AB216603)")
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 | Notes Boil tissue section in EDTA buffer, pH 8.0 for 10 min followed by cooling at room temperature for 20 min. Primary incubation for 10 minutes at room temperature. |
Target data
Alternative names
KIAA0437, SETBP1, SET-binding protein, SEB
Recommended products
Rabbit Recombinant Monoclonal SETBP1 antibody. Suitable for IHC-P and reacts with Human samples.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- SP312
- Purification technique
- Affinity purification Protein A/G
- Concentration
- Purification notes
Purified from TCS by protein A/G.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SETBP1 also known as SET Binding Protein 1 is a protein encoded by the SETBP1 gene. It has a mass of approximately 170 kDa. SETBP1 binds to SET a protein involved in regulation of cell cycle and apoptosis. It is mainly expressed in the nucleus of cells particularly in tissues such as brain heart liver and muscle. Its localization in the nucleus indicates its role in gene regulation and chromatin organization.
- Biological function summary
SETBP1 impacts transcriptional regulation by interacting with other proteins and modifying chromatin structure. While it is not a part of a classic multi-protein complex it influences the function of complexes involved in DNA repair and replication. This protein has a regulatory effect on pathways influencing cell maturation and proliferation making its role significant in cellular homeostasis.
- Pathways
SETBP1 plays important roles in intracellular signaling specifically the PI3K/AKT pathway and the Wnt signaling pathway. In these pathways it modulates cell growth survival and differentiation by interacting with proteins like AKT and beta-catenin. These interactions help balance cell processes like apoptosis and proliferation essential for normal development and function.
- Associated diseases and disorders
SETBP1 alterations are linked to Schinzel-Giedion syndrome and some leukemias. Mutations in SETBP1 can affect DNA repair mechanisms leading to disorders related to impaired genomic stability. In leukemia SETBP1 mutations often associate with overexpression of proteins such as SET which drive disease progression by disrupting normal cell cycle regulation. Understanding SETBP1's roles and interactions can aid in developing therapies targeting these mutations.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
10 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img58099.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human liver tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137694.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human pancreas tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137109.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lymph node tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img131063.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human HK lymphoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img118441.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human B cell lymphoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img82812.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human pancreatic adenocarcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img29427.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human urinary bladder tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img136702.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138357.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human urinary bladder transitional cell carcinoma tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138237.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon tissue labeling SETBP1 with ab216603 at 1/100 dilution.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img82812.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img29427.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img136702.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138357.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603), expandable thumbnail](https://content.abcam.com/products/images/setbp1-antibody-sp312-ab216603--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138237.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SETBP1 antibody [SP312] (ab216603)")
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com