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AB317416

Anti-SF20 Antibody [S06-7B1]

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Rabbit Monoclonal SF20 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human MYDGF.

View Alternative Names

C19orf10, MYDGF, Myeloid-derived growth factor

1 Images
Western blot - Anti-SF20 Antibody [S06-7B1] (AB317416)
  • WB

Supplier Data

Western blot - Anti-SF20 Antibody [S06-7B1] (AB317416)

All lanes:

Western blot - Anti-SF20 Antibody [S06-7B1] (ab317416) at 1/1000 dilution

Lane 1:

HeLa cell lysate

Lane 2:

Jurkat cell lysate

Predicted band size: 19 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

S06-7B1

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human MYDGF.

Q969H8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SF20 also known as IL-25 or IL-TIF is a protein involved in cell signaling mechanisms. It has a molecular mass of around 25 kDa. SF20 shows expression in specific tissues such as the small intestine lung and skin suggesting its role in tissue-specific functions. Its expression pattern might suggest potential roles in mucosal immunity and epithelial functions.
Biological function summary

SF20 acts as a member of the IL-17 cytokine family which mediates inflammatory responses. It often forms part of signaling complexes that involve other cytokines to coordinate immune responses. SF20 exerts its influence by binding to a unique receptor complex activating downstream signaling cascades. This interaction is important in mobilizing immune cells to sites of infection or injury highlighting its role in immune system regulation.

Pathways

SF20 is involved in the Th17 cell differentiation and inflammatory response pathways. It plays a role in modulating the activities of STAT3 and NF-kB pathways which are essential in inflammation and immune regulation. SF20 interacts with other proteins such as IL-17A and IL-17F which aid in the amplification of immune signals and inflammation.

SF20 has implications in conditions like asthma and inflammatory bowel disease (IBD). Its involvement in chronic inflammation links it to these diseases. SF20 can interact with proteins like IL-23 in the context of Th17-mediated inflammatory responses. Targeting SF20 and its signaling pathways presents potential therapeutic opportunities for modulating immune responses in such diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed : 25581518).
See full target information MYDGF
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Product promise

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