AB92667

Anti-SFRP2 antibody

Name: Anti-SFRP2 antibody (ab92667) | Abcam
Brand: Abcam Limited
SKU: AB92667
Rating: 3 (2 reviews)

(2 Reviews)

(7 Publications)

Rabbit Polyclonal SFRP2 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human SFRP2.

View Alternative Names

FRP2, SARP1, FKSG12, UNQ361/PRO697, SFRP2, Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1

1 Images

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Western blot - Anti-SFRP2 antibody (AB92667)

All lanes:

Western blot - Anti-SFRP2 antibody (ab92667) at 1/500 dilution

Lane 1:

HuvEc cell lysate at 30 µg

Lane 2:

COLO cell lysate at 30 µg

Lane 3:

HeLa cell lysate at 30 µg

Lane 4:

HeLa cell lysate at 30 µg with immunizing peptide

Predicted band size: 33 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human SFRP2. The exact immunogen used to generate this antibody is proprietary information.

Q96HF1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFRP2 also known as Secreted Frizzled-Related Protein 2 is a protein that primarily functions as a modulator of the Wnt signaling pathway. It is a secreted glycoprotein with an approximate mass of 35 kDa. SFRP2 contains a cysteine-rich domain that is homologous to the Wnt-binding site of Frizzled proteins. This protein is widely expressed in various tissues including the heart lung and kidneys. Its primary role involves regulating the activity of Wnt proteins by direct binding which impacts cell signaling processes.

Biological function summary

SFRP2 plays a significant role in the regulation of cellular proliferation migration and differentiation. It often functions as a part of extracellular signaling complexes influencing tissue development and repair. SFRP2 has been implicated in controlling the balance between cell growth and apoptosis particularly in stem cell environments and developing organ systems. Its activity impacts embryonic development contributing to the formation and patterning of tissues by modulating the Wnt signaling cascade.

Pathways

Scientists have extensively studied SFRP2 in the context of the Wnt signaling and angiogenesis pathways. In the Wnt signaling pathway SFRP2 intervenes by sequestering Wnt ligands and preventing them from activating Frizzled receptors thereby modulating downstream β-catenin activities. The protein shows interaction with other Wnt pathway components like DKK1 which also modulates Wnt signaling. In the angiogenesis pathway SFRP2's involvement affects vascular formation and stability linking it to proteins such as VEGF a critical regulator of blood vessel growth.

Researchers have linked SFRP2 to cancer and cardiac conditions. In cancer abnormal SFRP2 expression has been associated with tumor progression and metastasis often through its interaction with other Wnt pathway proteins like β-catenin and DKK1 altering cell survival and division. In cardiac disorders altered levels of SFRP2 impact heart remodeling and fibrosis connecting to proteins such as TGF-β involved in fibrotic processes. Scientists continue to investigate SFRP2's role in these conditions to develop targeted therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

See full target information SFRP2

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

British journal of cancer 130:1249-1260 PubMed38361045

2024

AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication.

Applications

Unspecified application

Species

Unspecified reactive species

Nanna Monjé,Mihnea P Dragomir,Bruno V Sinn,Inga Hoffmann,Anuar Makhmut,Tincy Simon,Catarina A Kunze,Jana Ihlow,Wolfgang D Schmitt,Jonathan Pohl,Iris Piwonski,Sofya Marchenko,Carlotta Keunecke,Teodor G Calina,Francesca Tiso,Hagen Kulbe,Caroline Kreuzinger,Dan Cacsire Castillo-Tong,Jalid Sehouli,Elena I Braicu,Carsten Denkert,Silvia Darb-Esfahani,Kirsten Kübler,David Capper,Fabian Coscia,Markus Morkel,David Horst,Christine Sers,Eliane T Taube

The British journal of dermatology 187:936-947 PubMed35862273

2022

Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Qingmei Liu,Yulong Tang,Yan Huang,Ji'an Wang,Kai Yang,Yuting Zhang,Weilin Pu,Jing Liu,Xiangguang Shi,Yanyun Ma,Chunya Ni,Yue Zhang,Yifei Zhu,Haiyang Li,Jiucun Wang,Jinran Lin,Wenyu Wu

Journal of molecular cell biology 13:41-58 PubMed33582796

2021

Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangwen Peng,Kaa Seng Lai,Peilu She,Junsu Kang,Tingting Wang,Guobao Li,Yating Zhou,Jianjian Sun,Daqing Jin,Xiaolei Xu,Lujian Liao,Jiandong Liu,Ethan Lee,Kenneth D Poss,Tao P Zhong

The American journal of pathology 190:1909-1920 PubMed32533926

2020

Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Sono,Ching-Yun Hsu,Yiyun Wang,Jiajia Xu,Masnsen Cherief,Simone Marini,Amanda K Huber,Sarah Miller,Bruno Péault,Benjamin Levi,Aaron W James

Molecular medicine reports 20:1925-1932 PubMed31257495

2019

SFRP2 modulates non‑small cell lung cancer A549 cell apoptosis and metastasis by regulating mitochondrial fission via Wnt pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Li,Shu Zhao,Yi Hu

Behavioural brain research 359:609-618 PubMed30291843

2018

Loss of Sfrp2 contributes to the neurological disorders related with morphine withdrawal via Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Cai Wang,Yu-Qian Li,Da-Yun Feng,Xin Zhou,Feng-Qi Yan,Yang Li,Li Gao,Li-Hong Li

American journal of physiology. Cell physiology 307:C415-30 PubMed24871858

2014

Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

James D West,Eric D Austin,Christa Gaskill,Shennea Marriott,Rubin Baskir,Ganna Bilousova,Jyh-Chang Jean,Anna R Hemnes,Swapna Menon,Nathaniel C Bloodworth,Joshua P Fessel,Johnathan A Kropski,David Irwin,Lorraine B Ware,Lisa Wheeler,Charles C Hong,Barbara Meyrick,James E Loyd,Aaron B Bowman,Kevin C Ess,Dwight J Klemm,Pampee P Young,W David Merryman,Darrell Kotton,Susan M Majka

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SFRP2 antibody

Western blot - Anti-SFRP2 antibody (AB92667)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

Product promise