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AB138022

Anti-SFRS7/SRSF7 antibody

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(6 Publications)

Rabbit Polyclonal SFRS7/SRSF7 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SRSF7.

View Alternative Names

SFRS7, SRSF7, Serine/arginine-rich splicing factor 7, Splicing factor 9G8

1 Images
Western blot - Anti-SFRS7/SRSF7 antibody (AB138022)
  • WB

Unknown

Western blot - Anti-SFRS7/SRSF7 antibody (AB138022)

All lanes:

Western blot - Anti-SFRS7/SRSF7 antibody (ab138022) at 1/500 dilution

All lanes:

HT29 cell lysate at 30 µg

Predicted band size: 27 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SRSF7. The exact immunogen used to generate this antibody is proprietary information.

Q16629

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFRS7 also known as SRSF7 is a member of the serine/arginine-rich family of proteins that functions as an essential splicing factor. It has a mass of approximately 27 kDa. SRSF7 shows expression in various tissues with notable presence in the nucleoplasm of cells. Mechanically SRSF7 has binding affinity for RNA sequences facilitating alternative splicing by interacting with pre-mRNA. This protein plays a significant role in post-transcriptional regulation influencing the maturation and diversity of mRNA transcripts.
Biological function summary

SRSF7 contributes to the regulation of gene expression and is involved in spliceosome formation though it is not strictly part of the spliceosomal core complex. It influences exon skipping and inclusion which affects various functional mRNA variants. SRSF7 enables cellular responses to changes in internal and external environments by altering gene expression patterns. This flexibility positions it as an important player in processes such as cell cycle regulation and apoptosis.

Pathways

SRSF7 operates within the general mRNA processing pathway and plays a part in the spliceosome pathway. SRSF7 interacts with other splicing factors like SRSF1 which promotes its functional diversity. These proteins collectively enable precise and correct splicing of mRNA which is critical in maintaining cellular homeostasis and responding to physiological changes.

Abnormalities in SRSF7 expression or function can relate to cancer and neurodegenerative disorders. Dysregulation of mRNA splicing where SRSF7 plays a role can drive oncogenic transformations in cells linking it to various forms of cancer. Also SRSF7 and splicing-related proteins such as hnRNPs are observed in dysfunctional states within neurodegenerative conditions suggesting splicing alterations contribute to disease pathogenesis. Understanding SRSF7's role allows for better comprehension of these disorders and potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
See full target information SRSF7
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 84:2765-2784.e16 PubMed38964322

2024

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Robert Ietswaart,Brendan M Smalec,Albert Xu,Karine Choquet,Erik McShane,Ziad Mohamoud Jowhar,Chantal K Guegler,Autum R Baxter-Koenigs,Emma R West,Becky Xu Hua Fu,Luke Gilbert,Stephen N Floor,L Stirling Churchman

Heliyon 10:e31972 PubMed38868058

2024

Downregulation of hsa_circTLK1 represses non-small cell lung cancer progression by regulating miR-876-3p/SRSF7 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xinzhe Dong,Hui Tian,Peng Ren,Yanxia Liu,Lin Wang

Aging 15:14591-14606 PubMed38159247

2024

SRSF7 downregulation induces cellular senescence through generation of variants.

Applications

Unspecified application

Species

Unspecified reactive species

Jiwon Hong,Seongki Min,Gyesoon Yoon,Su Bin Lim

Scientific reports 12:2278 PubMed35145187

2022

ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuhiro Kazuma,Kotaro Shirakawa,Yusuke Tashiro,Hiroyuki Yamazaki,Ryosuke Nomura,Yoshihito Horisawa,Suguru Takeuchi,Emani Stanford,Yoshinobu Konishi,Hiroyuki Matsui,Tadahiko Matsumoto,Fumiko Tanabe,Ryo Morishita,Shinji Ito,Akifumi Takaori-Kondo

Nature communications 11:799 PubMed32034135

2020

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Sze Jing Tang,Haoqing Shen,Omer An,HuiQi Hong,Jia Li,Yangyang Song,Jian Han,Daryl Jin Tai Tay,Vanessa Hui En Ng,Fernando Bellido Molias,Ka Wai Leong,Priyankaa Pitcheshwar,Henry Yang,Leilei Chen

Nucleic acids research 44:8933-8950 PubMed27317697

2016

The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators.

Applications

WB

Species

Mouse

Miriam Llorian,Clare Gooding,Nicolas Bellora,Martina Hallegger,Adrian Buckroyd,Xiao Wang,Dipen Rajgor,Melis Kayikci,Jack Feltham,Jernej Ule,Eduardo Eyras,Christopher W J Smith
View all publications
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Product promise

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