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AB72616

Anti-SFRS7/SRSF7 antibody

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(2 Publications)

Mouse Polyclonal SFRS7/SRSF7 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SRSF7.

View Alternative Names

SFRS7, SRSF7, Serine/arginine-rich splicing factor 7, Splicing factor 9G8

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SFRS7/SRSF7 antibody (AB72616)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SFRS7/SRSF7 antibody (AB72616)

Immunocytochemistry of HeLa cells staining SFRS7/SRSF7 using ab72616 at 10 μg/ml.

Western blot - Anti-SFRS7/SRSF7 antibody (AB72616)
  • WB

Unknown

Western blot - Anti-SFRS7/SRSF7 antibody (AB72616)

All lanes:

Western blot - Anti-SFRS7/SRSF7 antibody (ab72616) at 1/500 dilution

Lane 1:

SFRS7/SRSF7 transfected 293T cell line at 25 µg

Lane 2:

Non transfected 293T cell line at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 27 kDa

Observed band size: 30 kDa

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SRSF7.

Q16629

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Alternative Products

Primary Antibodies

AB137247

Anti-SFRS7/SRSF7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SFRS7/SRSF7 antibody (AB137247)

  • 0
  • 0
Primary Antibodies

AB138022

Anti-SFRS7/SRSF7 antibody

Western blot - Anti-SFRS7/SRSF7 antibody (AB138022)

  • 0
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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

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Anti-SF3B1 antibody [EPR11986]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFRS7 also known as SRSF7 is a member of the serine/arginine-rich family of proteins that functions as an essential splicing factor. It has a mass of approximately 27 kDa. SRSF7 shows expression in various tissues with notable presence in the nucleoplasm of cells. Mechanically SRSF7 has binding affinity for RNA sequences facilitating alternative splicing by interacting with pre-mRNA. This protein plays a significant role in post-transcriptional regulation influencing the maturation and diversity of mRNA transcripts.
Biological function summary

SRSF7 contributes to the regulation of gene expression and is involved in spliceosome formation though it is not strictly part of the spliceosomal core complex. It influences exon skipping and inclusion which affects various functional mRNA variants. SRSF7 enables cellular responses to changes in internal and external environments by altering gene expression patterns. This flexibility positions it as an important player in processes such as cell cycle regulation and apoptosis.

Pathways

SRSF7 operates within the general mRNA processing pathway and plays a part in the spliceosome pathway. SRSF7 interacts with other splicing factors like SRSF1 which promotes its functional diversity. These proteins collectively enable precise and correct splicing of mRNA which is critical in maintaining cellular homeostasis and responding to physiological changes.

Abnormalities in SRSF7 expression or function can relate to cancer and neurodegenerative disorders. Dysregulation of mRNA splicing where SRSF7 plays a role can drive oncogenic transformations in cells linking it to various forms of cancer. Also SRSF7 and splicing-related proteins such as hnRNPs are observed in dysfunctional states within neurodegenerative conditions suggesting splicing alterations contribute to disease pathogenesis. Understanding SRSF7's role allows for better comprehension of these disorders and potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
See full target information SRSF7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40649911

2025

Multi-Omics Integration: Predicting Progression and Optimizing Clinical Treatment of Hepatocellular Carcinoma Through Malignant-Cell-Related Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Qianwen Wang,Lingli Cheng,Honglin Yan,Jingping Yuan

Neuroscience 339:308-318 PubMed27746349

2016

C3 transferase gene therapy for continuous conditional RhoA inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Claire-Anne Gutekunst,Jack K Tung,Margaret E McDougal,Robert E Gross
View all publications
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Product promise

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