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AB236899

Anti-SFT2D2 antibody

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Rabbit Polyclonal SFT2D2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SFT2D2 aa 1-50.

View Alternative Names

UNQ512/PRO1027, SFT2D2, Vesicle transport protein SFT2B, SFT2 domain-containing protein 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SFT2D2 antibody (AB236899)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SFT2D2 antibody (AB236899)

MCF7 (Human breast adenocarcinoma cell line) cells stained for SFT2D2 (green) using ab236899 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-SFT2D2 antibody (AB236899)
  • WB

Supplier Data

Western blot - Anti-SFT2D2 antibody (AB236899)

All lanes:

Western blot - Anti-SFT2D2 antibody (ab236899) at 1/1000 dilution

Lane 1:

Mouse liver tissue lysate

Lane 2:

Mouse kidney tissue lysate

Lane 3:

Mouse thymus tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 17 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SFT2D2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O95562

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFT2D2 also known as Suppressor of Fused (Sof1) in yeast is a protein involved in membrane trafficking and sorting within cells. It has a mass of approximately 21 kDa and is localized in the membranes of the Golgi apparatus and cytoplasmic vesicles. Expression of SFT2D2 occurs in various tissues with high levels observed in the liver and kidney. The protein possesses transmembrane domains that allow it to facilitate movement of vesicles between organelles.
Biological function summary

SFT2D2 plays a role in the Golgi apparatus' function and vesicular transport processes. It is part of a larger protein complex that helps mediate vesicle fusion and cargo transport. This protein ensures accurate sorting and delivery of proteins and lipids which are essential for maintaining cellular homeostasis. It is especially vital in regulating the processing and maturation of proteins that transit through the secretory pathway.

Pathways

SFT2D2 functions in the intracellular trafficking and secretory pathways. It interacts with the SNARE protein family to perform its role in vesicle docking and fusion. Additionally SFT2D2 has relevance in the secretory pathway where it contributes to the optimal functioning of the endoplasmic reticulum (ER) to Golgi transport. This coordination with proteins such as Syntaxin 5 ensures seamless progression of synthesized proteins to their destinations.

Alterations in SFT2D2 expression or structure might relate to metabolic dysfunctions including liver diseases. Disruption to SFT2D2 pathways also indicates a potential link to neurodegenerative disorders due to impaired vesicular trafficking. Relatedly improper association with SNARE proteins can exacerbate these conditions highlighting the importance of SFT2D2 in disease pathogenesis. Understanding its role could aid in discovering therapeutic targets in related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
See full target information SFT2D2
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Product promise

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