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AB254666

Anti-SG2NA antibody

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(1 Publication)

Rabbit Polyclonal SG2NA antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STRN3 aa 550-750.

View Alternative Names

GS2NA, SG2NA, STRN3, Striatin-3, Cell cycle autoantigen SG2NA, S/G2 antigen

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SG2NA antibody (AB254666)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SG2NA antibody (AB254666)

Paraffin-embedded human small intestine tissue stained for SG2NA using ab254666 at 1/50 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SG2NA antibody (AB254666)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SG2NA antibody (AB254666)

PFA fixed, Triton X-100 permeabilized U-2 OS (Human bone osteosarcoma epithelial cell line) cells labeling SG2NA using ab254666 at 4µg/ml (green) in ICC/IF.

Western blot - Anti-SG2NA antibody (AB254666)
  • WB

Supplier Data

Western blot - Anti-SG2NA antibody (AB254666)

Western blot analysis using anti-SG2NA antibody ab254666 (A) shows similar pattern to anti-SG2NA antibody ab254667 (B).

Lane 1:

Western blot - Anti-SG2NA antibody (ab254666)

Lanes 2 - 3:

Western blot - Anti-SG2NA antibody (ab254666) at 0.4 µg/mL

Lane 1:

DNA Ladder

Lane 2:

RT4 (Human urinary bladder cancer cell line) whole cell lysate

Lane 3:

U-251MG whole cell lysate

Predicted band size: 87 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STRN3 aa 550-750. The exact immunogen used to generate this antibody is proprietary information.

Q13033

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SG2NA also known as Serine/Threonine Phosphatase 2A regulatory subunit B'' is a component of the protein phosphatase 2A (PP2A) complex. SG2NA has a molecular mass of approximately 54 kDa. The protein functions as a regulatory subunit and influences the specificity and activity of the PP2A holoenzyme. SG2NA is expressed in various tissues with notable concentrations in the brain indicating its role in neuronal activities.
Biological function summary

This regulatory protein contributes to several cellular processes through its interaction as part of the PP2A complex. SG2NA plays a significant role in cell cycle regulation controlling cell proliferation and apoptosis. It is involved in dephosphorylating specific substrates that are essential for cellular signal transduction and maintaining protein stability. This control over phosphorylation events impacts cellular responses to external stimuli and internal signals.

Pathways

SG2NA interacts with many signaling cascades notably the PI3K/AKT and MAPK pathways. It regulates the reversal of phosphorylation in these pathways impacting cellular processes such as growth and survival. By modulating the activation states of proteins like AKT and ERK SG2NA indirectly affects complex networks of biological pathways and collaborates with protein partners like PP2A catalytic subunits to maintain cellular homeostasis.

Research has associated SG2NA with neurodegenerative diseases and cancer. Altered function or regulation of SG2NA links to disorders such as Alzheimer’s disease where the protein interacts with tau a related protein aggregating in neurofibrillary tangles. In cancer SG2NA interacts through pathways impacting proteins like p53 reflecting its role in tumor suppression. Understanding the role of SG2NA in these diseases can lead to insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed : 18782753, PubMed : 30622739, PubMed : 33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable).
See full target information STRN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 40:1295-1307 PubMed39698827

2024

TRIM22 mechanism promoting KAT2A ubiquitination degradation to regulate ferroptosis in hepatocellular carcinoma cell invasion and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Xiaoshan Chen,Wei Wei
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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