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AB137207

Anti-SGLT2 antibody

3

(2 Reviews)

|

(6 Publications)

Rabbit Polyclonal SGLT2 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SLC5A2.

View Alternative Names

SGLT2, SLC5A2, Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2

1 Images
Western blot - Anti-SGLT2 antibody (AB137207)
  • WB

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Western blot - Anti-SGLT2 antibody (AB137207)

All lanes:

Western blot - Anti-SGLT2 antibody (ab137207) at 1/500 dilution

All lanes:

Jurkat cell lysate at 30 µg

Predicted band size: 73 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SLC5A2. The exact immunogen used to generate this antibody is proprietary information.

P31639

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SGLT2 also known as sodium-glucose co-transporter 2 is a protein responsible for reabsorbing glucose in the renal proximal convoluted tubule. It carries glucose along with sodium ions across cell membranes enabling glucose reabsorption from the glomerular filtrate back into the bloodstream a process essential for the maintenance of glucose homeostasis. This protein has a molecular weight of approximately 75 kDa. SGLT2 is mostly expressed in the renal epithelial cells located within the kidney's proximal tubule.
Biological function summary

Sodium-glucose co-transporter 2 plays a central role in renal glucose reabsorption. It operates as part of a vital mechanism in the kidney where it engages in the active transport of glucose against its concentration gradient facilitated by the sodium gradient produced by the Na⁺/K⁺-ATPase pump. This transporter ensures minimal loss of glucose in urine maintaining energy balance and blood glucose levels.

Pathways

SGLT2 is involved in glucose and sodium transport pathways critical for glycolytic and gluconeogenic processes. These pathways are key for energy production and glucose homeostasis. It works closely with proteins like GLUT2 which operates in the basolateral membrane of renal tubular cells to further transfer reabsorbed glucose into the bloodstream. Together these proteins form a tightly regulated network that maintains normal blood glucose levels.

SGLT2 has a significant impact on diabetes and cardiovascular disease. Inhibitors of SGLT2 are effective treatments for type 2 diabetes by preventing glucose reabsorption leading to increased glucose excretion through urine and improved glycemic control. The glucose-lowering effect also contributes to reducing risks associated with cardiovascular diseases. In this context SGLT2 interacts with protein targets like insulin where its modulation offers therapeutic efficacy in managing hyperglycemia.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1 : 1 (PubMed : 20980548, PubMed : 28592437, PubMed : 34880493, PubMed : 37217492, PubMed : 38057552). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed : 20980548, PubMed : 28592437, PubMed : 34880493). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (PubMed : 37217492). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
See full target information SLC5A2
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 15:30 PubMed38212646

2024

Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans.

Applications

Unspecified application

Species

Unspecified reactive species

J Zimmer,L Mueller,P Frank-Herrmann,J Rehnitz,J E Dietrich,M Bettendorf,T Strowitzki,M Krivega

Human & experimental toxicology 42:9603271231183056 PubMed37295442

2023

Renal glucose transporters play a role in removal of cadmium from kidney cells mediated by GMDTC - A novel metal chelator.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojiang Tang,Bo Xiao,Qile Zhao,Wei Hu,Amber McKenery,Zhiyong Zhong

JCI insight 7: PubMed35077394

2022

Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chengkang He,Qiang Li,Yuanting Cui,Peng Gao,Wentao Shu,Qing Zhou,Lijuan Wang,Li Li,Zongshi Lu,Yu Zhao,Huan Ma,Xiaowei Chen,Hongbo Jia,Hongting Zheng,Gangyi Yang,Daoyan Liu,Martin Tepel,Zhiming Zhu

Pharmaceuticals (Basel, Switzerland) 14: PubMed33920838

2021

Dual-Target Compounds against Type 2 : Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Ádám Sipos,Eszter Szennyes,Nikolett Éva Hajnal,Sándor Kun,Katalin E Szabó,Karen Uray,László Somsák,Tibor Docsa,Éva Bokor

PloS one 15:e0232283 PubMed32343721

2020

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

Applications

Unspecified application

Species

Unspecified reactive species

Dan Nakano,Takumi Kawaguchi,Hideki Iwamoto,Masako Hayakawa,Hironori Koga,Takuji Torimura

International journal of legal medicine 133:1107-1114 PubMed30073510

2018

Validation of sodium/glucose cotransporter proteins in human brain as a potential marker for temporal narrowing of the trauma formation.

Applications

Unspecified application

Species

Unspecified reactive species

Sabrina Oerter,Carola Förster,Michael Bohnert
View all publications
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