Rabbit Polyclonal SGLT2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 41 publications. Immunogen corresponding to Synthetic Peptide within Mouse Slc5a2.
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Publications
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- PeerJ 11:e156472023Adrenal SGLT1 or SGLT2 as predictors of atherosclerosis under chronic stress based on a computer algorithm.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianyi Li,Lingbing Meng,Dishan Wu,Hongxuan Xu,Xing Hu,Gaifeng Hu,Yuhui Chen,Jiapei Xu,Tao Gong,Deping LiuPubMed 37663275
- BMC nephrology 24:2502023Knockdown of TMEM30A in renal tubular epithelial cells leads to reduced glucose absorption.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSipei Chen,Xinrou Song,Qiong Xiao,Li Wang,Xianjun Zhu,Yang Zou,Guisen LiPubMed 37612668
- International journal of molecular sciences 24:2023Sex Modulates Response to Renal-Tubule-Targeted Insulin Receptor Deletion in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSoha Sohail,Gabriella Akkawi,Taylor Rechter,Maurice B Fluitt,Carolyn M EcelbargerPubMed 37175762
- Nature communications 13:79182022Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSienna R Li,Ramila E Gulieva,Louisa Helms,Nelly M Cruz,Thomas Vincent,Hongxia Fu,Jonathan Himmelfarb,Benjamin S FreedmanPubMed 36564419
- International journal of molecular sciences 23:2022Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing-Ying Chen,Tsung-Tien Wu,Chiu-Yi Ho,Tung-Chen Yeh,Gwo-Ching Sun,Ching-Jiunn Tseng,Pei-Wen ChengPubMed 35806147
- Yonsei medical journal 63:619-6312022Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhipeng Xu,Wenxin Hu,Bin Wang,Ting Xu,Jianning Wang,Dan WeiPubMed 35748073
- Biology of reproduction 106:1206-12172022The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility†.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeptember Numata,Jeff P McDermott,Gladis Sanchez,Amrita Mitra,Gustavo BlancoPubMed 35420639
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e219122021High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnja Bernhardt,Saskia Häberer,JingJing Xu,Hannah Damerau,Johannes Steffen,Charlotte Reichardt,Katharina Wolters,Hannes Steffen,Berend Isermann,Katrin Borucki,Nadine Artelt,Nicole Endlich,Renata Kozyraki,Sabine Brandt,Jonathan A Lindquist,Peter R MertensPubMed 34533842
- Molecular metabolism 54:1013372021Sodium-glucose co-transporter2 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of sodium-glucose co-transporter2 inhibitor treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNunzia D'Onofrio,Celestino Sardu,Maria Consiglia Trotta,Lucia Scisciola,Fabrizio Turriziani,Franca Ferraraccio,Iacopo Panarese,Lella Petrella,Mara Fanelli,Piero Modugno,Massimo Massetti,Ludovica Vittoria Marfella,Ferdinando Carlo Sasso,Maria Rosaria Rizzo,Michelangela Barbieri,Fulvio Furbatto,Fabio Minicucci,Ciro Mauro,Massimo Federici,Maria Luisa Balestrieri,Giuseppe Paolisso,Raffaele MarfellaPubMed 34500107
- The journals of gerontology. Series A, Biological sciences and medical sciences 77:215-2202021Canagliflozin Increases Intestinal Adenoma Burden in Female ApcMin/+ Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJustin Korfhage,Mary E Skinner,Jookta Basu,Joel K Greenson,Richard A Miller,David B LombardPubMed 34448851
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Slc5a2. The exact immunogen used to generate this antibody is proprietary information. Database link Q923I7
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
Species Mouse | Dilution info 1 µg/mL | Notes - |
Species Rat | Dilution info 1 µg/mL | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (PubMed:37217492). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
Alternative names
SGLT2, SLC5A2, Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2
Recommended products
Rabbit Polyclonal SGLT2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 41 publications. Immunogen corresponding to Synthetic Peptide within Mouse Slc5a2.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Slc5a2. The exact immunogen used to generate this antibody is proprietary information. Database link Q923I7
- Purification technique
- Affinity purification Protein A
- Specificity
The antibody detects 74 kDa SGLT-2 from human, mouse, and rat origins. Reactivity to other species has not been determined. A ~55 kDa and a ~45 kDa band can also be detected, representing the SGLT-2 cleavage fragments.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 3690 SGLT-2 Antibody. 3690-100 is the same size as the 100 μg size of ab37296.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SGLT2 also known as sodium-glucose co-transporter 2 is a protein responsible for reabsorbing glucose in the renal proximal convoluted tubule. It carries glucose along with sodium ions across cell membranes enabling glucose reabsorption from the glomerular filtrate back into the bloodstream a process essential for the maintenance of glucose homeostasis. This protein has a molecular weight of approximately 75 kDa. SGLT2 is mostly expressed in the renal epithelial cells located within the kidney's proximal tubule.
- Biological function summary
Sodium-glucose co-transporter 2 plays a central role in renal glucose reabsorption. It operates as part of a vital mechanism in the kidney where it engages in the active transport of glucose against its concentration gradient facilitated by the sodium gradient produced by the Na⁺/K⁺-ATPase pump. This transporter ensures minimal loss of glucose in urine maintaining energy balance and blood glucose levels.
- Pathways
SGLT2 is involved in glucose and sodium transport pathways critical for glycolytic and gluconeogenic processes. These pathways are key for energy production and glucose homeostasis. It works closely with proteins like GLUT2 which operates in the basolateral membrane of renal tubular cells to further transfer reabsorbed glucose into the bloodstream. Together these proteins form a tightly regulated network that maintains normal blood glucose levels.
- Associated diseases and disorders
SGLT2 has a significant impact on diabetes and cardiovascular disease. Inhibitors of SGLT2 are effective treatments for type 2 diabetes by preventing glucose reabsorption leading to increased glucose excretion through urine and improved glycemic control. The glucose-lowering effect also contributes to reducing risks associated with cardiovascular diseases. In this context SGLT2 interacts with protein targets like insulin where its modulation offers therapeutic efficacy in managing hyperglycemia.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SGLT2 antibody (ab37296)
Blocking buffer: 3% milk
All lanes: Western blot - Anti-SGLT2 antibody (ab37296) at 1 µg/mL
Lane 1: Jurkat at 20 µg
Lanes 2 - 3: NIH3T3 at 20 µg
SecondaryAll lanes: Goat Polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/50000 dilution
Predicted band size: 73 kDa
Observed band size: 73 kDa
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