Rabbit Polyclonal SGTA antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus.
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Publications
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- BioMed research international 2021:55453122021Identification and Validation of Potential Biomarkers and Pathways for Idiopathic Pulmonary Fibrosis by Comprehensive Bioinformatics Analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeibin Qian,Xinrui Cai,Qiuhai Qian,Xinying ZhangPubMed 34285914
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43765
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Cow | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
Target data
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).
Alternative names
SGT, SGT1, SGTA, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, Vpu-binding protein, UBP
Recommended products
Rabbit Polyclonal SGTA antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SGTA aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43765
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SGTA also known as Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha is a co-chaperone protein with a molecular mass of approximately 35 kDa. It plays a role in the protein quality control system by interacting with misfolded proteins. SGTA has a TPR domain essential for binding with other chaperones and client proteins. You can find this protein expressed in many tissues with highest levels in the liver kidney and testis.
- Biological function summary
SGTA influences protein folding and degradation impacting cellular protein homeostasis. It functions as part of the chaperone system and forms complexes with Hsp70 and Hsp90 helping in stabilizing and refolding damaged proteins. SGTA's interaction with steroid hormone receptors has roles in regulating their stability and function. It also interacts with other cellular proteins indicating its diverse biological responsibilities.
- Pathways
Small glutamine-rich tetratricopeptide repeat-containing protein alpha integrates into cellular mechanisms such as the ER-associated degradation (ERAD) and the ubiquitin-proteasome pathway. It associates with proteins like BAG6 which targets mislocalized proteins for degradation. It helps guide the quality control process in cells allowing the removal of faulty proteins and supporting cellular health.
- Associated diseases and disorders
SGTA shows associations with neurodegenerative diseases and certain cancers. It links to the accumulation of misfolded proteins which are common in disorders like Alzheimer's disease. In cancer SGTA's relationship with steroid hormone receptors can affect tumor growth and progression. Through pathways involving the androgen receptor SGTA potentially influences prostate cancer development.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SGTA antibody (ab96571)
10% SDS PAGE
All lanes: Western blot - Anti-SGTA antibody (ab96571) at 1/5000 dilution
Lane 1: HepG2 whole cell lysate at 30 µg
Lane 2: Molt-4 whole cell lysate at 30 µg
Predicted band size: 34 kDa
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