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AB215055

Anti-SH2D2A/SCAP antibody

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(1 Publication)

Sheep Polyclonal SH2D2A/SCAP antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus.

View Alternative Names

SCAP, TSAD, VRAP, SH2D2A, SH2 domain-containing protein 2A, SH2 domain-containing adapter protein, T cell-specific adapter protein, VEGF receptor-associated protein, TSAd

1 Images
Western blot - Anti-SH2D2A/SCAP antibody (AB215055)
  • WB

Supplier Data

Western blot - Anti-SH2D2A/SCAP antibody (AB215055)

All lanes:

Western blot - Anti-SH2D2A/SCAP antibody (ab215055) at 1/1000 dilution

All lanes:

mouse bone marrow lysate

Predicted band size: 43 kDa

Observed band size: 46 kDa

false

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SH2D2A aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NP31

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS at 500µg/mL
Purification technique
Affinity purification Immunogen
Purification notes
The IgG fraction of immunized serum was purified by antigen affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS)
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH2D2A also known as SCAP is an adapter protein of around 41 kDa mass with a central role in signaling pathways. It contains an SH2 domain that allows it to interact with specific phosphorylated tyrosine residues on other proteins. It has expression mainly in immune cells such as T lymphocytes. It functions by connecting receptors on the cell surface to downstream signaling molecules inside the cell. This makes SH2D2A an important player in transmitting extracellular signals to the cell interior.
Biological function summary

Interactions of SH2D2A affect immune cell activation and differentiation progressing to modulate immune responses. It is not part of a larger complex; instead it acts independently to amplify cellular responses. SH2D2A influences signaling pathways that involve cytokines and other immune modulators regulating the magnitude and direction of cellular activities in the immune system.

Pathways

SH2D2A plays a role in the T-cell receptor signaling and calcium signaling pathways. In the T-cell receptor signaling pathway it interacts with proteins like Lck and ZAP-70 aiding in the activation cascade that leads to T-cell activation. In the calcium signaling pathway SH2D2A can connect to phospholipase C-gamma which ultimately affects intracellular calcium levels and further communication within immune responses.

SH2D2A has associations with autoimmune diseases and immune deficiencies. Its misregulation in autoimmune diseases leads to an inappropriate immune response and tissue damage. Autoimmune disorders such as rheumatoid arthritis have links to SH2D2A due to its interactions with proteins like LAT which participate in overactive immune signaling. In immune deficiencies malfunctioning SH2D2A can result in insufficient immune response making understanding this target essential for therapeutic exploration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
See full target information SH2D2A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Anatomical record (Hoboken, N.J. : 2007) 302:1587-1593 PubMed30471213

2018

AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ.

Applications

Unspecified application

Species

Unspecified reactive species

Lingfeng Qin,Wang Min,Shijie Xin
View all publications
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Product promise

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