JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB279375

Anti-SH3BGR antibody [OTI1G7]

Be the first to review this product! Submit a review

|

(0 Publication)

Mouse Monoclonal SH3BGR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SH3BGR.

View Alternative Names

SH3 domain-binding glutamic acid-rich protein, SH3BGR protein, 21-glutamic acid-rich protein, 21-GARP, SH3BGR

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGR antibody [OTI1G7] (AB279375)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGR antibody [OTI1G7] (AB279375)

Paraffin embedded human adult heart tissue stained for SH3BGR using ab279375 at 1/500 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI1G7

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SH3BGR.

P55822

style
left-column

Complementary Products

Primary Antibodies

AB251765

Anti-RAB11FIP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB11FIP1 antibody (AB251765)

  • 0
  • 0
Primary Antibodies

AB279371

Anti-SH3BGRL antibody [OTI8F7]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371)

  • 0
  • 0
Primary Antibodies

AB179800

Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX2 / Cyclooxygenase 2 antibody [EPR12012] (AB179800)

  • 4
  • 3
Primary Antibodies

AB178425

Anti-ARL15 antibody [EPR12591]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-ARL15 antibody [EPR12591] (AB178425)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SH3BGR protein also known as SH3-domain binding glutamic acid-rich protein weighs around 11 kDa. This protein often shows expression in heart and skeletal muscle tissues. Mechanically SH3BGR interacts with proteins containing SH3 domains and contains a glutamic acid-rich region suggesting involvement in protein-protein interactions. Research shows that the protein localizes predominantly in the cytoplasm where it likely participates in cellular signaling events due to its structure.
Biological function summary

SH3BGR functions have a relation with signal transduction processes. It does not form part of any large recognized protein complex but its structural properties imply a role in binding activities affecting intracellular communication. SH3BGR might influence developmental and differentiation processes in tissues where it is expressed given the necessity for tightly regulated signaling pathways in these areas. Its precise biological activity is not fully elucidated but its interaction with SH3 domain proteins hints at a regulatory function.

Pathways

SH3BGR takes part in signaling cascades linked to the immune response and cell differentiation. It plays a role in the signal transduction pathways such as the MAPK pathway where interactions might include other SH3-domain proteins like Grb2. These pathways are important for transmitting extracellular signals to cellular responses. SH3BGR might also influence the actin cytoskeleton dynamics interacting with other proteins implicated in cytoskeletal organization impacting processes such as cell mobility and stability.

SH3BGR elements appear relevant in the context of muscular dystrophies and cardiac hypertrophy. These conditions can associate with faulty signaling in heart and muscle tissues where SH3BGR is expressed. In muscular dystrophies disruptions might involve altered interactions with dystrophin an important structural protein. In cardiac hypertrophy potential abnormal regulation in pathways involving SH3BGR and proteins like p38 MAPK could contribute to pathological changes in heart muscle cells influencing disease progression.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information SH3BGR
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com