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Mouse Monoclonal SH3BGRL antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SH3BGRL.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (AB279371), expandable thumbnail

Key facts

Isotype
IgG1
Host species
Mouse
Storage buffer

pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human SH3BGRL. Database link O75368

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species
Human
Dilution info
1/150
Notes

-

Target data

Function

Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014). May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550). Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550).

Alternative names

Adapter SH3BGRL, SH3 domain-binding glutamic acid-rich-like protein 1, SH3BGRL

Recommended products

Mouse Monoclonal SH3BGRL antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SH3BGRL.

Key facts

Isotype
IgG1
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Full Length Protein corresponding to Human SH3BGRL. Database link O75368
Clone number
OTI8F7
Purification technique
Affinity purification Protein A/G
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

SH3BGRL also known as SH3 domain-binding glutamic acid-rich protein-like is a scaffold protein involved in signaling pathways. It has a molecular weight of approximately 13 kDa and is widely expressed in various tissues including the brain liver and immune cells. The protein contains a phosphotyrosine-binding domain enabling interactions with phosphorylated proteins. This ability allows SH3BGRL to modulate signaling processes essential for cellular communication and function.

Biological function summary

SH3 domain-containing proteins like SH3BGRL facilitate multiple cellular processes by interacting with proteins involved in signal transduction pathways. It potentially forms part of larger protein complexes serving as an adaptor or mediator in these complexes. SH3BGRL can influence cell proliferation differentiation and immune responses by affecting downstream signaling events. Its rich domain structure suggests a role in maintaining the balance of specific signaling cascades helping cells respond properly to external stimuli.

Pathways

SH3BGRL participates in the regulation of the mitogen-activated protein kinase (MAPK) and JAK-STAT pathways. These pathways are important for cell signaling related to growth division and apoptosis. Within the MAPK pathway SH3BGRL can interact with kinases like ERK showing its influence on cellular functions. In the JAK-STAT pathway SH3BGRL may assist in the modulation of cytokine signaling by impacting interactions with receptor-associated phosphates. SH3BGRL's interactions with these proteins emphasize its significance in maintaining normal cellular dynamics.

Associated diseases and disorders

Research links SH3BGRL to cancer and autoimmune diseases. Dysregulation of MAPK and JAK-STAT pathways where SH3BGRL has a role frequently occurs in various cancers contributing to uncontrolled cell growth and survival. In autoimmune diseases abnormal SH3BGRL expression might relate to faulty immune signal regulation along with proteins such as STAT3. These connections suggest that SH3BGRL may serve as a potential biomarker or therapeutic target in disease contexts.

Product promise

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13 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human lymph node tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded adenocarcinoma of human endometrium tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human endometrium tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human thyroid tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded carcinoma of human thyroid tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human pancreas tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded adenocarcinoma of human ovary tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human ovary tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded carcinoma of human lung tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded adenocarcinoma of Human colon tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded carcinoma of human liver tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human kidney tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL antibody [OTI8F7] (ab279371)

    Paraffin embedded human lung tissue stained for SH3BGRL using ab279371 at 1/150 dilution in immunohistochemical analysis. Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer pH8.5 at 120°C for 3 minutes.

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