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AB122138

Anti-SH3BGRL3 antibody

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(1 Publication)

Rabbit Polyclonal SH3BGRL3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3BGRL3 aa 1 to C-terminus.

View Alternative Names

P1725, SH3BGRL3, SH3 domain-binding glutamic acid-rich-like protein 3, SH3 domain-binding protein 1, TNF inhibitory protein B1, SH3BP-1, TIP-B1

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SH3BGRL3 antibody (AB122138)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SH3BGRL3 antibody (AB122138)

ab122138 at 4 μg/ml staining SH3BGRL3 in PFA/Triton X-100 fixed/permeabilized U2OS cells by Immunofluorescence. Antibody staining is shown in green

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL3 antibody (AB122138)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3BGRL3 antibody (AB122138)

ab122138, at 1/600 dilution, staining SH3BGRL3 in Human smooth muscle tissue by Immunohistochemistry using paraffin-embedded tissue.

Western blot - Anti-SH3BGRL3 antibody (AB122138)
  • WB

Unknown

Western blot - Anti-SH3BGRL3 antibody (AB122138)

All lanes:

Western blot - Anti-SH3BGRL3 antibody (ab122138) at 1/250 dilution

Lane 1:

RT4 cell lysates

Lane 2:

U251MG cell lysates

Lane 3:

Human plasma

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 10 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SH3BGRL3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H299

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Complementary Products

Proteins & Peptides

AB134546

Recombinant Human SH3BGRL3 protein

SDS-PAGE - Recombinant Human SH3BGRL3 protein (AB134546)

  • 0
  • 0
Primary Antibodies

AB173574

Anti-WDR1 antibody [EPR8793]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR1 antibody [EPR8793] (AB173574)

  • 0
  • 0
Primary Antibodies

AB223477

Anti-ZKSCAN3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZKSCAN3 antibody (AB223477)

  • 0
  • 0
Primary Antibodies

AB185483

Anti-Secretory lectin ZG16 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Secretory lectin ZG16 antibody (AB185483)

  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/600", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Fixed/permeabilized with PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3BGRL3 also known as SH3 domain binding glutamic acid-rich protein-like 3 is a small protein with a molecular mass of approximately 17 kDa. This protein is expressed in a variety of tissues including the liver heart and muscle. It contains an SH3 binding domain known to interact with SH3 domains of other proteins providing a regulatory mechanism in cell signaling. The protein is also highly expressed in certain tumor cells indicating its potential role in cellular transformation and cancer.
Biological function summary

The protein is involved in several cellular processes including signal transduction and cytoskeleton organization. SH3BGRL3 functions as part of a protein complex that modulates interactions between signaling molecules and cytoskeletal components. It plays an important role in maintaining cellular architecture and facilitating cell communication by interacting with other proteins inside the cell. This interaction can affect cell structure and growth.

Pathways

This protein participates in signal transduction and cytoskeletal dynamics pathways. It interacts with proteins such as Src which is involved in various signaling cascades. SH3BGRL3's connection to the Src signaling pathway is significant as it can modulate processes like cell proliferation and differentiation. The protein is also linked with actin cytoskeleton pathways further highlighting its role in maintaining cell structure integrity.

Research connects SH3BGRL3 to cancer and cardiovascular diseases. Its expression levels in tumor cells are linked to cancer progression potentially serving as a biomarker for tumor development. In cardiovascular disorders alterations in SH3BGRL3 can affect heart muscle function possibly influencing disease outcomes. The protein has associations with Src in both cancer and heart diseases suggesting a broader role in disease mechanisms through these pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed : 34380438).
See full target information SH3BGRL3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 15:10389-10406 PubMed37801482

2023

Novel diagnostic biomarkers of oxidative stress, immunological characterization and experimental validation in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Di Hu,Xiaocong Mo,Luo Jihang,Cheng Huang,Hesong Xie,Ling Jin
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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