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AB184008

Anti-SH3GL3 antibody

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(3 Publications)

Rabbit Polyclonal SH3GL3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SH3GL3 aa 50 to C-terminus.

View Alternative Names

CNSA3, SH3D2C, SH3GL3, Endophilin-A3, EEN-B2, Endophilin-3, SH3 domain protein 2C, SH3 domain-containing GRB2-like protein 3

2 Images
Western blot - Anti-SH3GL3 antibody (AB184008)
  • WB

Supplier Data

Western blot - Anti-SH3GL3 antibody (AB184008)

12 % SDS PAGE

All lanes:

Western blot - Anti-SH3GL3 antibody (ab184008) at 1/1000 dilution

All lanes:

Mouse brain lysate at 50 µg

Predicted band size: 39 kDa

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Western blot - Anti-SH3GL3 antibody (AB184008)
  • WB

Supplier Data

Western blot - Anti-SH3GL3 antibody (AB184008)

12% SDS PAGE

All lanes:

Western blot - Anti-SH3GL3 antibody (ab184008) at 1/5000 dilution

All lanes:

Rat brain lysate at 50 µg

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SH3GL3 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q99963

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3GL3 also known as endophilin A3 is a protein with a molecular mass of approximately 40 kDa. It functions mechanically through its SH3 domain which facilitates interaction with proline-rich motifs in other proteins part of various cellular processes. Expressed mainly in the brain and neural tissues SH3GL3 plays significant roles in intracellular signaling and membrane dynamics. Its presence in neuronal tissue suggests an involvement in key neurological processes.
Biological function summary

SH3GL3 interacts with other proteins as part of the endophilin protein family involved in endocytosis and synaptic vesicle recycling. It acts as an adaptor linking intracellular signaling proteins to membrane-bound receptors influencing the way neurons communicate and adapt to changes. SH3GL3 helps regulate the formation and maintenance of synaptic connections ensuring proper neural network function.

Pathways

SH3GL3 participates in the regulation of the endocytosis pathway engaging in vital neuron communication mechanisms. It connects with proteins like dynamin and synaptojanin to modulate vesicle scission and recycling. Through the Ras signaling pathway it further affects synaptic plasticity and cellular responses to external stimuli supporting the adaptability of neural tissues.

SH3GL3 associates with neurological conditions including Alzheimer's disease and schizophrenia. In Alzheimer's altered interactions with proteins like amyloid precursor protein (APP) might disrupt synaptic function contributing to cognitive decline. In schizophrenia modifications in endocytic and signaling pathways involving SH3GL3 and proteins like neuregulin-1 could affect neurotransmission leading to symptoms commonly observed in the disorder.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
See full target information SH3GL3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biochemical and biophysical research communication 544:73-80 PubMed33524871

2021

SH3GL3 acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi Nie,Shan Cai,Zhimin Wei,Yanxi Li,Li Bian,Chenyang Wang,Xiangpeng Wang,Chunyan Wang

The EMBO journal 38: PubMed30733243

2019

Endophilin-A regulates presynaptic Ca influx and synaptic vesicle recycling in auditory hair cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jana Kroll,Lina M Jaime Tobón,Christian Vogl,Jakob Neef,Ilona Kondratiuk,Melanie König,Nicola Strenzke,Carolin Wichmann,Ira Milosevic,Tobias Moser

Developmental cell 45:738-752.e6 PubMed29920278

2018

Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Kumud R Poudel,Minna Roh-Johnson,Allen Su,Thuong Ho,Haritha Mathsyaraja,Sarah Anderson,William M Grady,Cecilia B Moens,Maralice Conacci-Sorrell,Robert N Eisenman,Jihong Bai
View all publications
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Product promise

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