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AB222911

Anti-SH3PX1/SNX9 antibody

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(1 Publication)

Rabbit Polyclonal SH3PX1/SNX9 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SNX9 aa 50-200.

View Alternative Names

SH3PX1, SH3PXD3A, SNX9, Sorting nexin-9, SH3 and PX domain-containing protein 1, SH3 and PX domain-containing protein 3A, Protein SDP1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3PX1/SNX9 antibody (AB222911)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SH3PX1/SNX9 antibody (AB222911)

Paraffin-embedded human thyroid tissue stained for SH3PX1/SNX9 using ab222911 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SH3PX1/SNX9 antibody (AB222911)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SH3PX1/SNX9 antibody (AB222911)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for SH3PX1/SNX9 (green) using ab222911 at 1/100 dilution in ICC/IF. Secondary : Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SNX9 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5X1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SH3PX1 also known as SNX9 is a protein with a mass of approximately 69 kDa. This protein contains an SH3 domain which enables it to bind to other proteins and participate in intracellular signaling pathways. SNX9 is widely expressed in various tissues including the brain and liver indicating a broad functional role in cellular processes. The expression of SNX9 in different cell types suggests its involvement in multiple cellular processes including membrane trafficking and cytoskeletal dynamics.
Biological function summary

Functions of SNX9 extend to cellular endocytosis and membrane remodeling. It is part of the retromer complex which plays a role in sorting endosomal proteins back to the trans-Golgi network or plasma membrane. SNX9 facilitates the curvature of cellular membranes aiding the process of clathrin-mediated endocytosis. This protein's ability to bind with both phospholipids and cytoskeletal components highlights its importance in maintaining cellular architecture and facilitating signal transduction.

Pathways

SNX9 integrates into the endocytic and signaling pathways. Its involvement in clathrin-mediated endocytosis and interactions with proteins like dynamin and WASP indicate its key role in vesicle formation and intracellular transport. SNX9 also participates within the Wnt signaling pathway functioning alongside proteins like LRP6 and GSK3 to mediate signal transduction processes that regulate cell fate determination. These pathways underline SNX9's significance in processes controlling cellular growth and differentiation.

Alterations in SNX9 expression or function have associations with neurological disorders and cancer. SNX9 interactions with proteins like Cdc42 and cortactin highlight its relevance in brain development and its implications in schizophrenia. Abnormalities in SNX9-mediated endocytosis can disrupt cellular signaling leading to oncogenic transformation and contributing to the progression of cancers such as breast cancer. Understanding SNX9's role in these conditions may offer insights into potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
See full target information SNX9
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:311 PubMed40801925

2025

Quercetin alleviates acute pancreatitis by modulating glycolysis and mitochondrial function via PFKFB3 inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Hai Jiang,Jia Liu,Zhipeng Xu,Qi Song,Junjie Tao,Heng Zhu,Qiliang Li,Lei Li
View all publications
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Product promise

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