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AB157766

Anti-SHANK1 antibody [M369]

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(1 Publication)

Mouse Monoclonal SHANK1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Shank1.

View Alternative Names

SH3 and multiple ankyrin repeat domains protein 1, Shank1, GKAP/SAPAP-interacting protein, SPANK-1, Somatostatin receptor-interacting protein, Synamon, SSTR-interacting protein, SSTRIP

1 Images
Western blot - Anti-SHANK1 antibody [M369] (AB157766)
  • WB

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Western blot - Anti-SHANK1 antibody [M369] (AB157766)

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Western blot - Anti-SHANK1 antibody [M369] (ab157766) at 1/250 dilution

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Western blot - Anti-SHANK1 antibody [M369] (ab157766) at 1/500 dilution

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Western blot - Anti-SHANK1 antibody [M369] (ab157766) at 1/1000 dilution

All lanes:

Mouse brain lysate.

Predicted band size: 225 kDa

Observed band size: 225 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

M369

Isotype

IgG1

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Rat Shank1. The exact immunogen used to generate this antibody is proprietary information.

Q9WV48

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHANK1 also known as SH3 and multiple ankyrin repeat domains protein 1 plays an important role in the structural organization of synapses. It is a scaffold protein found in postsynaptic density where it interacts with other molecules to maintain synaptic architecture. The protein has a molecular mass of approximately 240 kDa. Expression of SHANK1 is most abundant in the brain especially in the hippocampus and cortex where it is essential for establishing and stabilizing synaptic connections during neuronal development.
Biological function summary

SHANK1 participates in the formation of macromolecular complexes that are critical for synaptic signaling and plasticity. It forms complexes with other postsynaptic proteins including PSD-95 and Homer which together coordinate the organization of synaptic receptors and signaling molecules. This interaction determines synaptic strength and plays a role in the modulation of synaptic transmission influencing the communication between neurons.

Pathways

SHANK1 is involved in the glutamatergic synaptic transmission pathway which is important for neural communication and cognitive functions such as learning and memory. Through this pathway SHANK1 interacts with NMDA receptors and mGluR receptors facilitating the propagation of excitatory signals. It also connects with proteins like SAPAP and cortactin which help stabilize the synaptic complex influencing cytoskeletal dynamics and synaptic plasticity.

SHANK1 has been implicated in autism spectrum disorders and schizophrenia where disrupted synaptic signaling plays an important role. Mutations in SHANK1 or its regulatory interactions can lead to altered neuronal connectivity and synaptic function which contribute to the pathology of these conditions. The protein's interaction with SHANK3 and other synaptic proteins like neuroligin emphasizes its role in synaptic disorders as these partners also participate in maintaining synaptic structure and function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.
See full target information Shank1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Parasite immunology 36:100-6 PubMed24558656

2014

Effects of tannic acid on Haemonchus contortus larvae viability and immune responses of sheep white blood cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

R Z Zhong,H X Sun,H W Liu,D W Zhou
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