AB105208

Anti-SHISA9 antibody

Name: Anti-SHISA9 antibody (ab105208) | Abcam
Brand: Abcam Limited
SKU: AB105208
Price: 520 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal SHISA9 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein shisa-9.

View Alternative Names

Protein shisa-9, SHISA9

1 Images

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Western blot - Anti-SHISA9 antibody (AB105208)

All lanes:

Western blot - Anti-SHISA9 antibody (ab105208) at 1 µg/mL

All lanes:

Rat brain tissue lysate at 15 µg

Predicted band size: 46 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Synthetic Peptide within Human Protein shisa-9. The exact immunogen used to generate this antibody is proprietary information.

B4DS77

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHISA9 also known as CKAMP44 is a protein involved in the regulation of synaptic transmission. It has a molecular mass of approximately 60 kDa. SHISA9 is expressed in the central nervous system with significant presence in the hippocampus and cerebellum. This protein plays a role in controlling the functional properties of AMPA receptors by influencing their kinetics and trafficking at the postsynaptic membrane.

Biological function summary

SHISA9 affects the modulation of synaptic plasticity. It is often part of a larger protein complex involved in stabilizing AMPA receptors on the cell surface. By interacting directly with AMPA receptors SHISA9 regulates synaptic strength which is essential for processes like learning and memory. Its function in the hippocampus is particularly significant as this region is closely linked with cognitive functions.

Pathways

SHISA9 participates in the glutamatergic synapse pathway. It modifies the activity of AMPA receptors an important component of this pathway which is important for excitatory neurotransmission. Through its interactions with other synaptic proteins such as GRIP1 SHISA9 further contributes to the regulation of receptor activity. These pathways are vital for maintaining synaptic homeostasis and neural communication.

Altered SHISA9 function is associated with neurodegenerative disorders and epilepsy. Dysregulation of SHISA9 affects AMPA receptor dynamics which can contribute to the pathophysiology of these conditions. Furthermore studies suggest potential interactions with proteins like Stargazin in these disorders as both are involved in the modulation of AMPA receptor function. Understanding SHISA9's role can help in developing treatments for these neurological diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).

See full target information Protein shisa-9

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

FASEB bioAdvances 7:e1481 PubMed39781426

2025

Diacylglycerol kinase δ is required for skeletal muscle development and regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Hiromichi Sakai,Chiaki Murakami,Mayumi Takechi,Takeshi Urano,Fumio Sakane

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SHISA9 antibody

Western blot - Anti-SHISA9 antibody (AB105208)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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