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AB98148

Anti-SHKBP1 antibody

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Rabbit Polyclonal SHKBP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SHKBP1 aa 150-450.

View Alternative Names

SB1, PP203, SHKBP1, SH3KBP1-binding protein 1, SETA-binding protein 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SHKBP1 antibody (AB98148)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SHKBP1 antibody (AB98148)

Immunohistochemical analysis of SHKBP1 in paraffin embedded PC13 xenograft, using ab98148 at a 1/100 dilution.

Western blot - Anti-SHKBP1 antibody (AB98148)
  • WB

Unknown

Western blot - Anti-SHKBP1 antibody (AB98148)

7.5% SDS PAGE

All lanes:

Western blot - Anti-SHKBP1 antibody (ab98148) at 1/500 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 76 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SHKBP1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q8TBC3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHKBP1 also known as Sh3kbp1-binding protein 1 is a protein that plays an influential mechanical role in cellular processes such as signal transduction. It has a molecular mass of approximately 76 kDa. This protein is expressed in various tissues with notable abundance in the brain and immune-related cells. As a part of its mechanical function SHKBP1 interacts with components of several signaling pathways helping to regulate cellular responses to external stimuli.
Biological function summary

SHKBP1 is engaged in the modulation of signal transduction and cell communication. It participates in molecular complexes that are involved in the regulation of endocytosis and intracellular trafficking. SHKBP1 interacts with proteins like Cbl which plays a significant role in mediating ubiquitin-protein ligase activities. This interaction can influence how receptors and proteins are marked for degradation affecting cellular communication networks.

Pathways

The protein SHKBP1 integrates into signaling routes such as the ubiquitin-proteasome pathway and the signaling cascades involving Cbl proteins. These pathways govern critical cell cycle events and protein stability. SHKBP1 forms part of the complex machinery that manages the sorting and degradation of receptor tyrosine kinases participating in processes alongside other related proteins like Grb2. This involvement highlights its significant role within the larger framework of cell signaling dynamics.

Abnormalities in SHKBP1 expression or function connect with the development of cancer and neurodegenerative diseases. For example its altered regulatory role in ubiquitination can lead to unrestrained cell proliferation contributing to oncogenesis. Moreover disruptions in signaling pathways where SHKBP1 cooperates with Cbl and other binding partners could relate to neural tissue damage implicating SHKBP1 in neurodegenerative conditions including Alzheimer's disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
See full target information SHKBP1
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Product promise

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