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AB55740

Anti-SHOX2 antibody [1D1]

5

(3 Reviews)

|

(24 Publications)

Mouse Monoclonal SHOX2 antibody. Suitable for WB, IHC-Fr and reacts with Recombinant fragment - Human, Rat, Human samples. Cited in 24 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SHOX2 aa 100-250.

View Alternative Names

OG12X, SHOT, SHOX2, Short stature homeobox protein 2, Homeobox protein Og12X, Paired-related homeobox protein SHOT

2 Images
Western blot - Anti-SHOX2 antibody [1D1] (AB55740)
  • WB

Unknown

Western blot - Anti-SHOX2 antibody [1D1] (AB55740)

SHOX2 antibody (ab55740) at 1ug/lane + PC-12 cell lysate at 25ug/lane.

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-SHOX2 antibody [1D1] (ab55740)

Predicted band size: 34 kDa

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Western blot - Anti-SHOX2 antibody [1D1] (AB55740)
  • WB

Supplier Data

Western blot - Anti-SHOX2 antibody [1D1] (AB55740)

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-SHOX2 antibody [1D1] (ab55740)

All lanes:

Recombinant SHOX2 Protein

Predicted band size: 34 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

1D1

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-Fr, WB

applications

Immunogen

Recombinant Fragment Protein within Human SHOX2 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

O60902

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Product details

This product was changed from ascites to tissue culture supernatant on 16/Oct/2019. Lot numbers higher than GR3303529 are from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The short stature homeobox 2 (SHOX2) is a transcription factor protein involved in various regulatory functions. It is also known as OG12X and is characterized by its homeobox domain. SHOX2 weighs approximately 28 kDa. Its expression occurs mainly in the embryonic heart skeletal system and developing limbs. Researchers observe SHOX2 in specific adult tissues such as the sinoatrial node of the heart where it plays roles in maintaining regular cardiac rhythm.
Biological function summary

The protein influences developmental processes by regulating gene expression during embryogenesis. SHOX2 is not part of a large complex but functions independently to modulate the development of tissues and organs. It ensures proper formation of heart structures skeletal growth and limb patterning. SHOX2's absence or malfunction can lead to disruptions in the structural development of these areas.

Pathways

SHOX2 has significant roles in cardiac pacemaker and limb development pathways. It is heavily involved in the canonical Wnt signaling pathway which supports the growth and differentiation of various tissues. The relationship between SHOX2 and BMP4 another protein in this pathway is important for bone development and limb formation. SHOX2 also interfaces with T-box proteins like TBX5 contributing to the specification and function of heart tissues.

SHOX2 links to conditions such as short stature homeobox-related syndromes and congenital heart defects. Dysfunctions in SHOX2 can lead to Léri-Weill dyschondrosteosis a disorder associated with short stature and skeletal abnormalities. In heart development the interaction between SHOX2 and NKX2-5 another important transcription factor is pivotal. Abnormalities or mutations in SHOX2 may also contribute to sinus node dysfunction impacting heart rate regulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
See full target information SHOX2
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Publications (24)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:10206 PubMed39604360

2024

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Amos A Lim,Delaram Pouyabahar,Mishal Ashraf,Kate Huang,Michelle Lohbihler,Brandon M Murareanu,Matthew L Chang,Maggie Kwan,Faisal J Alibhai,Thinh Tran,Amine Mazine,Michael A Laflamme,Gary D Bader,Zachary Laksman,Stephanie Protze

Cellular and molecular life sciences : CMLS 81:286 PubMed38970652

2024

Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.

Applications

Unspecified application

Species

Unspecified reactive species

Estelle Renaux,Charlotte Baudouin,Damien Marchese,Yoanne Clovis,Soo-Kyung Lee,Françoise Gofflot,René Rezsohazy,Frédéric Clotman

iScience 27:109917 PubMed38812544

2024

IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Zhao,Guohua Ji,Sihai Zhou,Shiou Cai,Kai Li,Wanyu Zhang,Chuanjie Zhang,Na Yan,Shuhui Zhang,Xiaopeng Li,Bo Song,Lina Qu

Scientific reports 14:7648 PubMed38561388

2024

Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jian-Rong Sun,Chen-Fan Kong,Yi-Xiang Ye,Qin Wang,Xiang-Ke Qu,Li-Qun Jia,Song Wu

iScience 26:107617 PubMed37664594

2023

SHOX2 promotes prostate cancer proliferation and metastasis through disruption of the Hippo-YAP pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Yang,Hualin Chen,Lin Ma,Jie Dong,Mengchao Wei,Xiaoqiang Xue,Yingjie Li,Zhaoheng Jin,Weifeng Xu,Zhigang Ji

Biology open 12: PubMed37272627

2023

Tbx5 overexpression in embryoid bodies increases TAK1 expression but does not enhance the differentiation of sinoatrial node cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yunkai Dai,Fatemeh Nasehi,Charles D Winchester,Ann C Foley

The journal of gene medicine 25:e3499 PubMed36908084

2023

Disrupting methyl-CpG-binding protein 2 expression induces the transformation of induced pluripotent stem cell cardiomyocytes into pacemaker-like cells by insulin gene enhancer binding protein 1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,Jianjun Gu,Yanxi Shi,Bichun Li,Xiang Gu

Journal of tissue engineering 13:20417314221127908 PubMed36277058

2022

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models.

Applications

Unspecified application

Species

Unspecified reactive species

Jiuru Li,Alexandra Wiesinger,Lianne Fokkert,Bastiaan J Boukens,Arie O Verkerk,Vincent M Christoffels,Gerard J J Boink,Harsha D Devalla

eLife 11: PubMed36217819

2022

A single cell transcriptional roadmap of human pacemaker cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Wiesinger,Jiuru Li,Lianne Fokkert,Priscilla Bakker,Arie O Verkerk,Vincent M Christoffels,Gerard J J Boink,Harsha D Devalla

Stem cell research & therapy 13:324 PubMed35851424

2022

RA signaling pathway combined with Wnt signaling pathway regulates human-induced pluripotent stem cells (hiPSCs) differentiation to sinus node-like cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yin,Feng-Yuan Wang,Wei Zhang,Xi Wang,Yan-Hong Tang,Teng Wang,Yu-Ting Chen,Cong-Xin Huang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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