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AB139806

Anti-SHQ1 antibody

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(1 Publication)

Rabbit Polyclonal SHQ1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Protein SHQ1 homolog.

View Alternative Names

Protein SHQ1 homolog, SHQ1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SHQ1 antibody (AB139806)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SHQ1 antibody (AB139806)

Immunofluorescence of SHQ1 in Human heart tissue with ab139806 at 20 ug/mL.

Western blot - Anti-SHQ1 antibody (AB139806)
  • WB

Unknown

Western blot - Anti-SHQ1 antibody (AB139806)

All lanes:

Western blot - Anti-SHQ1 antibody (ab139806) at 1 µg/mL

Lane 1:

Human heart tissue lysate at 15 µg

Lane 2:

Human heart tissue lysate at 15 µg with blocking peptide

Predicted band size: 65 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human Protein SHQ1 homolog. The exact immunogen used to generate this antibody is proprietary information.

Q6PI26

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SHQ1 is a protein involved in the processing and maturation of small nucleolar RNAs (snoRNAs). Also known as HSPC037 it has a molecular mass of approximately 65 kDa. SHQ1 is expressed in various tissues with its highest expression in the heart and skeletal muscle. It interacts directly with H/ACA ribonucleoproteins playing a role in the assembly and stability of these complexes which are essential for proper ribosome biogenesis.
Biological function summary

SHQ1 influences the proper assembly of H/ACA snoRNPs complexes important for the modification and maturation of ribosomal RNA (rRNA). SHQ1 primarily assists in the stabilization and assembly of dyskerin a catalytic subunit within H/ACA snoRNP complexes. Its function ensures accurate pseudouridylation a process that facilitates proper folding and functionality of rRNA within the ribosome. The protein's interaction within these complexes highlights its role in maintaining ribosomal integrity and function.

Pathways

The importance of SHQ1 lies within the snoRNA processing and ribosome assembly pathways. It plays a part in the ribosome biogenesis pathway which is vital for efficient protein synthesis. SHQ1 associates with dyskerin and other snoRNP proteins such as NOP10 and NHP2 linking them to the successful modification of rue rRNA. By influencing these interactions SHQ1 is integral to the proper synthesis and function of ribosomes.

Mutations or dysregulation of SHQ1 have been associated with disorders like X-linked Dyskeratosis Congenita and certain cancers. In Dyskeratosis Congenita defects in ribosome function arise due to inadequate rRNA pseudouridylation in which SHQ1 plays a significant part. Additionally anomalous expression of SHQ1 can lead to aberrant cell growth associating it with oncogenesis and tumor development. This connection to proteins such as dyskerin emphasizes the impact of SHQ1 in maintaining cellular health and its potential role in disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
See full target information Protein SHQ1 homolog
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:108312 PubMed38026190

2023

TET2 is recruited by CREB to promote , , and transcription by facilitating hydroxymethylation during adipocyte differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yunjia Liu,Ting He,Zhuofang Li,Zhen Sun,Shuai Wang,Huanming Shen,Lingfeng Hou,Shengnan Li,Yixin Wei,Bingzhao Zhuo,Shanni Li,Can Zhou,Huiling Guo,Rui Zhang,Boan Li
View all publications
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Product promise

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