Rabbit Polyclonal SHQ1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Protein SHQ1 homolog.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Protein SHQ1 homolog. The exact immunogen used to generate this antibody is proprietary information. Database link Q6PI26
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Target data
Function
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA.
Alternative names
Protein SHQ1 homolog, SHQ1
Recommended products
Rabbit Polyclonal SHQ1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human Protein SHQ1 homolog.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Protein SHQ1 homolog. The exact immunogen used to generate this antibody is proprietary information. Database link Q6PI26
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SHQ1 is a protein involved in the processing and maturation of small nucleolar RNAs (snoRNAs). Also known as HSPC037 it has a molecular mass of approximately 65 kDa. SHQ1 is expressed in various tissues with its highest expression in the heart and skeletal muscle. It interacts directly with H/ACA ribonucleoproteins playing a role in the assembly and stability of these complexes which are essential for proper ribosome biogenesis.
- Biological function summary
SHQ1 influences the proper assembly of H/ACA snoRNPs complexes important for the modification and maturation of ribosomal RNA (rRNA). SHQ1 primarily assists in the stabilization and assembly of dyskerin a catalytic subunit within H/ACA snoRNP complexes. Its function ensures accurate pseudouridylation a process that facilitates proper folding and functionality of rRNA within the ribosome. The protein's interaction within these complexes highlights its role in maintaining ribosomal integrity and function.
- Pathways
The importance of SHQ1 lies within the snoRNA processing and ribosome assembly pathways. It plays a part in the ribosome biogenesis pathway which is vital for efficient protein synthesis. SHQ1 associates with dyskerin and other snoRNP proteins such as NOP10 and NHP2 linking them to the successful modification of rue rRNA. By influencing these interactions SHQ1 is integral to the proper synthesis and function of ribosomes.
- Associated diseases and disorders
Mutations or dysregulation of SHQ1 have been associated with disorders like X-linked Dyskeratosis Congenita and certain cancers. In Dyskeratosis Congenita defects in ribosome function arise due to inadequate rRNA pseudouridylation in which SHQ1 plays a significant part. Additionally anomalous expression of SHQ1 can lead to aberrant cell growth associating it with oncogenesis and tumor development. This connection to proteins such as dyskerin emphasizes the impact of SHQ1 in maintaining cellular health and its potential role in disease pathogenesis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-SHQ1 antibody (ab139806)
Immunofluorescence of SHQ1 in Human heart tissue with ab139806 at 20 ug/mL.
Western blot - Anti-SHQ1 antibody (ab139806)
All lanes: Western blot - Anti-SHQ1 antibody (ab139806) at 1 µg/mL
Lane 1: Human heart tissue lysate at 15 µg
Lane 2: Human heart tissue lysate at 15 µg with blocking peptide
Predicted band size: 65 kDa
Downloads
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