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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal SI antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SI aa 1-200.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.
SI
Rabbit Polyclonal SI antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SI aa 1-200.
SI
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
SI serves as a critical mediator in carbohydrate metabolism. It consists of two subunits sucrase and isomaltase working in tandem to hydrolyze disaccharides. Each subunit contributes its specific catalytic activity to the breakdown of complex sugars. Enzymatic activity of SI is essential for the small intestine's ability to efficiently convert disaccharides into glucose and fructose. The localization of SI in the intestinal brush border maximizes its contact with ingested carbohydrates facilitating their rapid digestion and ensuing absorption.
SI also known as sucrase-isomaltase is an enzyme complex with a molecular mass of approximately 245 kDa. It resides mainly in the brush border membrane of the small intestine. SI facilitates the digestion of dietary carbohydrates by splitting sucrose and isomaltase into simpler monosaccharides. This enzyme plays an important role in nutrient absorption and carbohydrate metabolism ensuring the small intestine can effectively process ingested sugars.
SI is integral to digestive pathways involving carbohydrate processing. It actively participates in the starch and sucrose metabolism pathway interacting with enzymes such as lactase and maltase which also hydrolyze carbohydrates. This connection underpins SI's contribution to the energy homeostasis by ensuring efficient carbohydrate digestion. Proper function of this pathway supports maintaining adequate glucose levels in the body highlighting its significant role in energy metabolism.
Mutations or deficiencies in SI lead to conditions like congenital sucrase-isomaltase deficiency (CSID) which results in carbohydrate malabsorption and gastrointestinal distress. Disorders related to SI often involve other proteins like lactase which also affect carbohydrate digestion. Understanding the relationship between SI and these digestive disorders aids in developing therapies and dietary adjustments aiming to alleviate symptoms associated with carbohydrate malabsorption.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
All lanes: ab224085 at 0.4 µg/mL
All lanes: Human small intestine tissue lysate
Predicted band size: 209 kDa
Immunohistochemical analysis of human small intestine tissue labeling SI with ab224085 at 1/200 dilution.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemical analysis of human small intestine tissue labeling SI with ab224085 at 1/200 dilution.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemical analysis of human stomach tissue labeling SI with ab224085 at 1/200 dilution. No positivity as expected.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Immunohistochemical analysis of human colon tissue labeling SI with ab224085 at 1/200 dilution. No positivity as expected.
Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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