AB53443

Anti-Sialoadhesin/CD169 antibody [3D6.112]

Name: Anti-Sialoadhesin/CD169 antibody [3D6.112] (ab53443) | Abcam
Brand: Abcam Limited
SKU: AB53443
Price: 430 USD
Availability: InStock

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(13 Publications)

Rat Monoclonal Sialoadhesin/CD169 antibody. Suitable for IHC-Fr and reacts with Mouse samples. Cited in 13 publications.

View Alternative Names

CD169, Sa, Sn, Siglec1, Sialoadhesin, Sheep erythrocyte receptor, Sialic acid-binding Ig-like lectin 1, SER, Siglec-1

1 Images

Immunohistochemistry (Frozen sections) - Anti-Sialoadhesin/CD169 antibody [3D6.112] (AB53443)

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Sialoadhesin/CD169 antibody [3D6.112] (AB53443)

ab53443 staining Sialoadhesin/CD169 in mouse spleen by Immunohistochemistry (Frozen sections).

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

3D6.112

Isotype

IgG2a

Carrier free

Reacts with

Mouse

Applications

IHC-Fr

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/50 - 1/100", "IHCFr-species-notes": "<p></p>" } } }

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Product details

Fusion partners: Spleen cells from an immunised AO rat were fused with the cells of the Y3 rat myeloma cell line.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 24788876). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 26370074). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus (PubMed : 26370074). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (By similarity).

See full target information Siglec1

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Cancer & metabolism 13:5 PubMed39875968

2025

Steatohepatitis-induced vascular niche alterations promote melanoma metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Johannes Hoffmann,Julia Schüler,Bianca Dietsch,Sina Wietje Kürschner-Zacharias,Carsten Sticht,Felix A Trogisch,Maren Schreitmüller,Tinja Baljkas,Kai Schledzewski,Manuel Reinhart,Sebastian A Wohlfeil,Manuel Winkler,Christian David Schmid,Joerg Heineke,Cyrill Géraud,Sergij Goerdt,Philipp-Sebastian Reiners-Koch,Victor Olsavszky

ACS nano 17:23545-23567 PubMed37988765

2023

Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A Vaccine.

Applications

Unspecified application

Species

Unspecified reactive species

Keegan Braz Gomes,Yi-Nan Zhang,Yi-Zong Lee,Mor Eldad,Alexander Lim,Garrett Ward,Sarah Auclair,Linling He,Jiang Zhu

Nature communications 14:1985 PubMed37031217

2023

Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Nan Zhang,Jennifer Paynter,Aleksandar Antanasijevic,Joel D Allen,Mor Eldad,Yi-Zong Lee,Jeffrey Copps,Maddy L Newby,Linling He,Deborah Chavez,Pat Frost,Anna Goodroe,John Dutton,Robert Lanford,Christopher Chen,Ian A Wilson,Max Crispin,Andrew B Ward,Jiang Zhu

Journal of clinical medicine 12: PubMed36902701

2023

Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Haruka Kaneko,Shinichiro Kuroshima,Ryohei Kozutsumi,Farah A Al-Omari,Hiroki Hayano,Kazunori Nakajima,Takashi Sawase

Science advances 7:eabj3107 PubMed34669468

2021

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Nan Zhang,Jennifer Paynter,Cindy Sou,Tatiana Fourfouris,Ying Wang,Ciril Abraham,Timothy Ngo,Yi Zhang,Linling He,Jiang Zhu

bioRxiv : the preprint server for biology : PubMed33791704

2021

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Nan Zhang,Jennifer Paynter,Cindy Sou,Tatiana Fourfouris,Ying Wang,Ciril Abraham,Timothy Ngo,Yi Zhang,Linling He,Jiang Zhu

EMBO reports 22:e52835 PubMed34196465

2021

Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Chen,Si Min Lai,Shaohai Xu,Yingrou Tan,Keith Leong,Dehua Liu,Jia Chi Tan,Roshan Ratnakar Naik,Anna M Barron,Sunil S Adav,Jinmiao Chen,Shu Zhen Chong,Lai Guan Ng,Christiane Ruedl

BMC cancer 18:608 PubMed29848296

2018

Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes.

Applications

Unspecified application

Species

Unspecified reactive species

Jinhua Zheng,Limin Jia,Shiro Mori,Tetsuya Kodama

Nature immunology 17:1118-27 PubMed27400148

2016

Tumor-induced stromal reprogramming drives lymph node transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Angela Riedel,David Shorthouse,Lisa Haas,Benjamin A Hall,Jacqueline Shields

Infection and immunity 82:3098-112 PubMed24818662

2014

Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.

Applications

Unspecified application

Species

Unspecified reactive species

Marwa K Ibrahim,Jeffrey L Barnes,E Yaneth Osorio,Gregory M Anstead,Fabio Jimenez,John J Osterholzer,Bruno L Travi,Seema S Ahuja,A Clinton White,Peter C Melby

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sialoadhesin/CD169 antibody [3D6.112]

Immunohistochemistry (Frozen sections) - Anti-Sialoadhesin/CD169 antibody [3D6.112] (AB53443)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Product protocols

Target data

Publications (13)

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