AB199401

Anti-Sialoadhesin/CD169 antibody [7239]

Name: Anti-Sialoadhesin/CD169 antibody [7239] (ab199401) | Abcam
Brand: Abcam Limited
SKU: AB199401
Price: 395 USD
Availability: InStock

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(3 Publications )

Mouse Monoclonal Sialoadhesin/CD169 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing SIGLEC1 protein.

2 Images

Flow Cytometry - Anti-Sialoadhesin/CD169 antibody [7239] (AB199401)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Sialoadhesin/CD169 antibody [7239] (AB199401)

Flow cytometric analysis showing the separation of CD169 negative lymphocytes in black, and CD169 positive monocytes in red using human peripheral whole blood, with ab199401 purified antibody in 1μg/ml concentration, GAM APC.

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Sialoadhesin/CD169 antibody [7239] (AB199401)

Flow cytometric pattern of human peripheral whole blood using ab199401 purified antibody in 1μg/ml concentration, GAM APC

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

7239

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing SIGLEC1 protein. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purity: > 95% (by SDS-PAGE)

Storage buffer

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 12940982, PubMed : 33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed : 28129379, PubMed : 34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed : 12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed : 26358190).. (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane.

See full target information SIGLEC1

Alternative Names

CD169, SN, SIGLEC1, Sialoadhesin, Sialic acid-binding Ig-like lectin 1, Siglec-1

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Publications (3)

Recent publications for all applications. Explore the full listand refine your search

mBio 16:e0038525 PubMed40833112

2025

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Feng,Jiannan Chen,Rong Li,Yunkai Zhu,Yanlong Ma,Ziqiao Wang,Yuyan Wang,Zhichao Gao,Lulu Yang,Yin Yu,Yanfeng Liu,Yingjie Sun,Ying Liao,Xinxin Huang,Qisheng Zhang,Yongheng Huang,Lin Qiu,Jiayu Wu,Jingxian Zhao,Chao Liu,Qiang Ding,Youhua Xie,Zhenghong Yuan,Yue Hong,Ping Zhang,Jing Sun,Jincun Zhao,Rong Zhang

Nature 598:342-347 PubMed34464958

2021

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Florian A Lempp,Leah B Soriaga,Martin Montiel-Ruiz,Fabio Benigni,Julia Noack,Young-Jun Park,Siro Bianchi,Alexandra C Walls,John E Bowen,Jiayi Zhou,Hannah Kaiser,Anshu Joshi,Maria Agostini,Marcel Meury,Exequiel Dellota,Stefano Jaconi,Elisabetta Cameroni,Javier Martinez-Picado,Júlia Vergara-Alert,Nuria Izquierdo-Useros,Herbert W Virgin,Antonio Lanzavecchia,David Veesler,Lisa A Purcell,Amalio Telenti,Davide Corti

International journal of molecular sciences 20: PubMed31766565

2019

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Nesli-Ece Sen,Aleksandar Arsovic,David Meierhofer,Susanne Brodesser,Carola Oberschmidt,Júlia Canet-Pons,Zeynep-Ece Kaya,Melanie-Vanessa Halbach,Suzana Gispert,Konrad Sandhoff,Georg Auburger

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sialoadhesin/CD169 antibody [7239]

Flow Cytometry - Anti-Sialoadhesin/CD169 antibody [7239] (AB199401)

Flow Cytometry - Anti-Sialoadhesin/CD169 antibody [7239] (AB199401)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Alternative Names

Publications (3)

Product promise