AB177937

Anti-SIGIRR antibody [EPR12638]

RabMAb
Recombinant
What is this?

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(4 Publications)

Rabbit Recombinant Monoclonal SIGIRR antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 4 publications.

View Alternative Names

UNQ301/PRO342, SIGIRR, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8

1 Images

Supplier Data

Western blot - Anti-SIGIRR antibody [EPR12638] (AB177937)

All lanes:

Western blot - Anti-SIGIRR antibody [EPR12638] (ab177937) at 1/1000 dilution

All lanes:

Fetal kidney lysate at 10 µg

Predicted band size: 46 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12638

Isotype

IgG

Carrier free

Reacts with

Human, Rat, Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SIGIRR also known as Single Immunoglobulin IL-1 Related Receptor or TIR8 is a transmembrane protein approximately 410 amino acids in length translating to a mass of about 45 kDa. It is expressed in various tissues with higher levels seen in the kidney liver lung and immune cells. SIGIRR is part of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) family acting as a negative regulator by interfering with signaling pathways usually triggered by these receptors.

Biological function summary

SIGIRR modulates immune responses by dampening inflammation and maintaining homeostasis in immune-related pathways. SIGIRR functions as a decoy receptor binding ligands without initiating a signaling cascade which effectively reduces the immune response. It does not work alone; it is part of larger receptor complexes within the TLR and IL-1R family where it can inhibit the signaling of other family members like TLR4 and IL-1R1 thereby controlling their activity and preventing excessive inflammation.

Pathways

SIGIRR participates in both the Toll-like receptor and interleukin-1 receptor pathways. It interacts with adaptor proteins such as MyD88 to modulate the downstream signaling cascade that involves NF-kB activation a central transcription factor in immune response. By doing so it keeps the inflammation response in check connecting to related proteins within these pathways that include IL-1R1 and TLR4 ultimately regulating key pro-inflammatory processes.

Multiple studies link SIGIRR to conditions characterized by chronic inflammation such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA). Animals with SIGIRR deficiency tend to show increased susceptibility to these diseases implicating its role in disease modulation. Additionally SIGIRR's interaction with IL-1R1 highlights its potential involvement in autoimmune diseases where dysregulated immune regulation is a common theme. Understanding its function in these contexts can provide insights into therapeutic approaches for inflammatory and autoimmune conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

See full target information SIGIRR

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Metabolites 13: PubMed37999237

2023

PPA1 Deficiency Causes a Deranged Galactose Metabolism Recognizable in Neonatal Screening.

Applications

Unspecified application

Species

Unspecified reactive species

Melanie T Achleitner,Judith J M Jans,Laura Ebner,Johannes Spenger,Vassiliki Konstantopoulou,René G Feichtinger,Karin Brugger,Doris Mayr,Ron A Wevers,Christian Thiel,Saskia B Wortmann,Johannes A Mayr

American journal of physiology. Gastrointestinal and liver physiology 324:G24-G37 PubMed36410023

2022

Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Yu,Aparna Venkatraman,Heather L Menden,Maribel Martinez,Shahid Umar,Venkatesh Sampath

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42:482-492 PubMed35900274

2022

Dominant-Negative Form of SIGIRR: SIGIRR Promotes Tumor Growth Through Regulation of Metabolic Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Malgorzata Bodaszewska-Lubas,Yun Liao,Aneta Zegar,Oskar Szelest,Jurek Dobrucki,Katarzyna Bulek

American journal of translational research 12:7249-7261 PubMed33312364

2020

Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tong Gao,Ran Zhao,Liangqing Yao,Congjian Xu,Qing Cong,Wei Jiang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SIGIRR antibody [EPR12638]

Western blot - Anti-SIGIRR antibody [EPR12638] (AB177937)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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