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AB106390

Anti-SIGLEC11 antibody

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(2 Publications)

Rabbit Polyclonal SIGLEC11 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SIGLEC11.

View Alternative Names

UNQ9222/PRO28718, SIGLEC11, Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11, Siglec-11

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (AB106390)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SIGLEC11 antibody (AB106390)

Immunofluorescence of SIGLEC11 in Human liver tissue with ab106390 at 20 ug/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (AB106390)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC11 antibody (AB106390)

ab106390 at 5μg/ml, staining SIGLEC11 in Human liver, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Western blot - Anti-SIGLEC11 antibody (AB106390)
  • WB

Unknown

Western blot - Anti-SIGLEC11 antibody (AB106390)

All lanes:

Western blot - Anti-SIGLEC11 antibody (ab106390) at 1 µg/mL

All lanes:

HepG2 cell lysate at 15 µg

Predicted band size: 75 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human SIGLEC11. The exact immunogen used to generate this antibody is proprietary information.

Q96RL6

Specificity

<p>Specific to Human SIGLEC11, does not cross react with SIGLEC10&#46;</p>

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Alternative Products

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Western blot - Anti-SIGLEC11 antibody [EPR8506(2)] (AB157187)

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB317449

Anti-SIGLEC10 + SIGLEC11 antibody [EPR29036-83] - BSA and Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC10 + SIGLEC11 antibody [EPR29036-83] - BSA and Azide free (AB317449)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SIGLEC11 also known as sialic acid-binding Ig-like lectin 11 is an inhibitory receptor protein characterized by its ability to bind sialic acids. It has a mass of approximately 66 kDa. This protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that helps transmit inhibitory signals. SIGLEC11 is predominantly expressed in the immune cells including macrophages and dendritic cells within the central nervous system (CNS). It is also found in certain peripheral tissues.
Biological function summary

SIGLEC11 plays a role in modulating immune responses and maintaining immune homeostasis. By binding to sialic acid-containing glycoproteins SIGLEC11 can influence cell-cell interactions and prevent unnecessary activation of immune cells. It does not form part of a larger complex but directly participates by recruiting phosphatases such as SHP-1 or SHP-2. These recruitments help dephosphorylate substrates in turn dampening immune cell activation.

Pathways

SIGLEC11 contributes to the negative regulation of receptor signaling pathways relevant to the immune system. Within the signaling pathways it impacts the downstream signaling cascade that involves Src family kinases. SIGLEC11 shares interactions with other members of the SIGLEC family engaging in pathways that modulate cellular activation and inflammation such as the MAPK pathway. This ensures balanced immune responses to avoid excessive inflammation.

SIGLEC11 expressions show relevance to neurodegenerative diseases and autoimmune disorders. Altered SIGLEC11 activity is associated with Alzheimer's disease where it may dampen the inflammatory response within the CNS providing a protective mechanism. In autoimmune conditions such as systemic lupus erythematosus (SLE) SIGLEC11 may interact with proteins that regulate self-tolerance and immune activation mitigating inappropriate immune responses. Understanding its function helps to reveal insights into disease mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
See full target information SIGLEC11
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of innate immunity 15:428-441 PubMed36944318

2023

Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Luxi Zou,Ling Sun,Ruixue Hua,Yu Wu,Linlin Sun,Ting Chen

Genes 14: PubMed36833422

2023

Whole Exome Sequencing Reveals Novel Candidate Genes in Familial Forms of Glaucomatous Neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Kiran Narta,Manoj Ramesh Teltumbade,Mansi Vishal,Samreen Sadaf,Mohd Faruq,Hodan Jama,Naushin Waseem,Aparna Rao,Abhijit Sen,Kunal Ray,Arijit Mukhopadhyay
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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