Anti-SIGLEC14 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SIGLEC14 also known as sialic acid-binding immunoglobulin-type lectin 14 is a protein important for immune response regulation. Its molecular mass is approximately 49 kDa. This protein is found mainly on the surface of immune cells like macrophages and neutrophils. By recognizing sialylated glycans SIGLEC14 functions as an inhibitory receptor reducing glycan-mediated signaling in immune responses. It modulates cell signaling through ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) and ITAM (Immunoreceptor Tyrosine-based Activation Motif) domains which helps balance activation and suppression of immune cells.

Biological function summary

SIGLEC14 influences the immune system by modulating anti-inflammatory responses. It interacts with the immunoglobulin family and other SIGLEC proteins like SIGLEC5 forming receptor complexes that manage cellular communication. These interactions contribute to distinguishing self from non-self and controlling unnecessary immune responses beneficial for preventing autoimmune reactions. SIGLEC14's role becomes apparent in maintaining the balance ensuring that immune responses are appropriate and controlled.

Pathways

The protein plays roles in immune response regulation and signal transduction pathways. It interacts with pathways like the toll-like receptor (TLR) signaling pathway and the NF-kB signaling pathway which are important for pathogen recognition and inflammatory response. SIGLEC14 modulates these pathways by interacting with other proteins such as Toll-like receptors and signaling adapters. This interaction helps transmit signals essential for immune activation and regulation.

Associated diseases and disorders

Dysregulation of SIGLEC14 associates with chronic inflammatory diseases and bacterial infections. Variants of SIGLEC14 show links to an altered susceptibility to diseases like chronic obstructive pulmonary disease (COPD) and bacterial pneumonia. It can interact with proteins such as SIGLEC5 influencing the outcome of infections by modulating the inflammatory responses. A balance in SIGLEC14 activity is necessary to prevent unintended inflammation and maintain immune homeostasis.