AB174732

Anti-SIGLEC15 antibody - N-terminal

Name: Anti-SIGLEC15 antibody - N-terminal (ab174732) | Abcam
Brand: Abcam Limited
SKU: AB174732
Price: 630 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal SIGLEC15 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SIGLEC15.

View Alternative Names

CD33L3, SIGLEC15, Sialic acid-binding Ig-like lectin 15, Siglec-15, CD33 antigen-like 3

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC15 antibody - N-terminal (AB174732)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC15 antibody - N-terminal (AB174732)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling SIGLEC15 with ab174732 at 5 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SIGLEC15. The exact immunogen used to generate this antibody is proprietary information.

Q6ZMC9

Specificity

ab174732 is predicted to not cross-react with other SIGLEC family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SIGLEC15 also known as sialic acid-binding Ig-like lectin 15 is a transmembrane protein with an approximate mass of 50 kDa. This protein is a member of the SIGLEC family that binds sialic acids on glycoproteins and glycolipids. SIGLEC15 is highly expressed in cells of the osteoclast lineage and some other immune cells. It typically functions as a receptor that can modulate immune cell interactions and signaling by recognizing and binding to sialylated glycans on other cells.

Biological function summary

SIGLEC15 plays roles in modulating the immune system and bone remodeling processes. It is not usually part of a larger complex but primarily acts as a cell surface receptor. SIGLEC15 helps regulate osteoclast differentiation and activity which are important for maintaining bone homeostasis. It modulates immune responses by interacting with other immune cells which can dampen or activate immune signaling pathways based on the cellular context.

Pathways

SIGLEC15 influences both immune signaling and bone metabolism pathways. It is involved in the RANKL-mediated osteoclastogenesis pathway which is critical for the formation and activation of osteoclasts. Within these pathways SIGLEC15 can relate to other proteins like RANK and RANKL that are essential in osteoclast development and function. Through its expression and interactions SIGLEC15 plays key roles in the regulation of immune and skeletal systems.

SIGLEC15 plays a significant role in osteoporosis and certain cancers. In osteoporosis SIGLEC15 expression in osteoclasts is elevated which can lead to increased bone resorption and weakened bones. In cancer its expression on tumor-associated macrophages and other cells can help tumors evade immune surveillance. In such conditions proteins like RANK RANKL and other immune checkpoint proteins may also be implicated providing potential targets for therapeutic intervention alongside SIGLEC15.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds sialylated glycoproteins.

See full target information SIGLEC15

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40943560

2025

Comprehensive Analysis of SIGLEC-15 and PD-L1 Expression Identifies Distinct Prognostic Profiles in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Andreea-Raluca Cozac-Szőke,Andreea Cătălina Tinca,Anca Negovan,Alexandra Vilaia,Dan-Alexandru Cozac,Iuliu-Gabriel Cocuz,Adrian Horațiu Sabău,Raluca-Diana Hagău,Diana-Maria Chiorean,Andreea-Bianca Lazar,Sabin Turdean,Emőke-Andrea Szász,Alexandru Nicușor Tomuț,Ovidiu Simion Cotoi

Chinese medical journal 134:2635-2637 PubMed34561324

2021

Siglec-15 promotes progression of clear renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Bo Yang,Cai-Peng Qin,Yi-Qing Du,Song-Chen Han,Tao Xu

Nature communications 11:6352 PubMed33311518

2020

An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Bin Wang,Ping Li,Xiao-Long Liu,Qiao-Ling Zheng,Yu-Bin Ma,Ya-Jun Zhao,Jian-Wei Xie,Jian-Xian Lin,Jun Lu,Qi-Yue Chen,Long-Long Cao,Mi Lin,Li-Chao Liu,Ning-Zi Lian,Ying-Hong Yang,Chang-Ming Huang,Chao-Hui Zheng

JCI insight 5: PubMed33004686

2020

CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodong Zhuang,Federica Maione,Joseph Robinson,Michael Bentley,Baksho Kaul,Katharine Whitworth,Neeraj Jumbu,Elizabeth Jinks,Jonas Bystrom,Pietro Gabriele,Elisabetta Garibaldi,Elena Delmastro,Zsuzsanna Nagy,David Gilham,Enrico Giraudo,Roy Bicknell,Steven P Lee

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SIGLEC15 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC15 antibody - N-terminal (AB174732)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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