AB53852

Anti-Sigma1-receptor antibody - C-terminal

Name: Anti-Sigma1-receptor antibody - C-terminal (ab53852) | Abcam
Brand: Abcam Limited
SKU: AB53852
Price: 620 USD
Availability: InStock
Rating: 4 (5 reviews)

(5 Reviews)

(37 Publications)

Rabbit Polyclonal Sigma1-receptor antibody. C-terminal. Suitable for WB and reacts with Mouse, Rat samples. Cited in 37 publications. Immunogen corresponding to Synthetic Peptide within Rat Sigmar1.

View Alternative Names

Oprs1, Sigmar1, Sigma non-opioid intracellular receptor 1, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R

1 Images

Unknown

Western blot - Anti-Sigma1-receptor antibody - C-terminal (AB53852)

All lanes:

Western blot - Anti-Sigma1-receptor antibody - C-terminal (ab53852) at 2 µg/mL

Lane 1:

Mouse brain homogenate

Lane 2:

Rat liver homogenate

Lane 3:

Rat brain homogenate

Predicted band size: 25 kDa

Observed band size: 25 kDa,75 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat

Applications

applications

Immunogen

Synthetic Peptide within Rat Sigmar1. The exact immunogen used to generate this antibody is proprietary information.

Q9R0C9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mink": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane (PubMed : 12730355). Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed : 11149946, PubMed : 14622179, PubMed : 15571673, PubMed : 15777781, PubMed : 23332758, PubMed : 9425306, PubMed : 9603192). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (PubMed : 25678561). Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (PubMed : 26792191).

See full target information Sigmar1

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Publications (37)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 50: PubMed37888772

2023

Starvation insult induces the translocation of high mobility group box 1 to cytosolic compartments in glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohang Cui,Anhui Yao,Liyun Jia

Frontiers in molecular neuroscience 16:1106765 PubMed37293542

2023

Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Dasiel O Borroto-Escuela,Alexander Lopez-Salas,Karolina Wydra,Marco Bartolini,Zilong Zhou,Malgorzata Frankowska,Agata Suder,Javier Benitez-Porres,Wilber Romero-Fernandez,Malgorzata Filip,Kjell Fuxe

Journal of neurochemistry 164:764-785 PubMed36084044

2022

Specific detection and deletion of the sigma-1 receptor widely expressed in neurons and glial cells in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Liu,Qilin Guo,Li-Pao Fang,Honghong Yao,Anja Scheller,Frank Kirchhoff,Wenhui Huang

Nature cardiovascular research 1:142-156 PubMed36051854

2022

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

LouJin Song,Ramsey Bekdash,Kumi Morikawa,Jose R Quejada,Alison D Klein,Danielle Aina-Badejo,Kazushige Yoshida,Hannah E Yamamoto,Amy Chalan,Risako Yang,Achchhe Patel,Dario Sirabella,Teresa M Lee,Leroy C Joseph,Fuun Kawano,Junco S Warren,Rajesh K Soni,John P Morrow,Masayuki Yazawa

Neuropharmacology 192:108612 PubMed34023338

2021

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain.

Applications

Unspecified application

Species

Unspecified reactive species

Írisz Szabó,Viktória É Varga,Szabolcs Dvorácskó,Attila E Farkas,Tímea Körmöczi,Róbert Berkecz,Szilvia Kecskés,Ákos Menyhárt,Rita Frank,Dóra Hantosi,Nicholas V Cozzi,Ede Frecska,Csaba Tömböly,István A Krizbai,Ferenc Bari,Eszter Farkas

Cell reports 34:108827 PubMed33691099

2021

BOK controls apoptosis by Ca transfer through ER-mitochondrial contact sites.

Applications

Unspecified application

Species

Unspecified reactive species

Marcos A Carpio,Robert E Means,Allison L Brill,Alva Sainz,Barbara E Ehrlich,Samuel G Katz

The Journal of biological chemistry 296:100469 PubMed33639169

2021

Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren Y Shields,Huihui Li,Kevin Nguyen,Hwajin Kim,Zak Doric,Joseph H Garcia,T Michael Gill,Dominik Haddad,Keith Vossel,Meredith Calvert,Ken Nakamura

The Journal of biological chemistry 295:17573-17587 PubMed33453999

2021

Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuharu Shinoda,Yudai Haga,Koichiro Akagawa,Kohji Fukunaga

Oxidative medicine and cellular longevity 2021:8836818 PubMed33488945

2021

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Qu,Miaoling Li,Dongxu Li,Yanguo Xin,Junli Li,Song Lei,Wenchao Wu,Xiaojing Liu

Integrative medicine research 10:100497 PubMed33384922

2021

The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma receptor involvement.

Applications

Unspecified application

Species

Unspecified reactive species

Su Yeon Seo,Soo Phil Kim,Se Kyun Bang,Suk Yun Kang,Seong Jin Cho,Kwang-Ho Choi,Yeonhee Ryu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Sigma1-receptor antibody - C-terminal

Western blot - Anti-Sigma1-receptor antibody - C-terminal (AB53852)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (37)

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