Anti-SIM2 antibody [EPR7878] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SIM2 also known as Single-minded homolog 2 is a transcription factor belonging to the bHLH-PAS family. It possesses a molecular weight of approximately 88 kDa. SIM2 plays a significant role in regulating gene expression by binding to the DNA hence influencing various biological processes. This protein is predominantly expressed in fetal and adult brain tissues as well as in other tissues including the kidney and lung suggesting its involvement in diverse physiological functions.

Biological function summary

This transcription factor modulates neural development and is implicated in the suppression of tumorigenesis. SIM2 interacts with ARNT (aryl hydrocarbon receptor nuclear translocator) to form a transcriptionally active complex. This complex plays a critical function in maintaining the delicate balance of cellular proliferation and differentiation. SIM2's expression levels change in response to developmental cues indicating its importance in development especially within the nervous system.

Pathways

This protein participates in the hypoxia and circadian rhythms pathways. In the hypoxia pathway SIM2 influences the cellular response to low oxygen levels by interacting with other transcription factors like HIF-1α while in the circadian rhythms pathway it affects the regulation of genes involved in maintaining the body's biological clock. These pathways exhibit how SIM2 integrates external signals demonstrating its function in complex biological networks.

Associated diseases and disorders

This transcription factor has been associated with Down syndrome and certain types of cancer such as prostate cancer. The downregulation or overexpression of SIM2 can contribute to the aberrant cellular proliferation characteristic of these disorders. Its interaction with other proteins such as ERG in prostate cancer links SIM2 to the progression and pathophysiology of these diseases highlighting its potential as a therapeutic target in understanding and treating these complex conditions.