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AB106169

Anti-SIR2 antibody

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(1 Publication)

Rabbit Polyclonal SIRT2 antibody. Suitable for ICC, WB and reacts with Trypanosoma brucei samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Trypanosoma brucei brucei TREU927 SIR2rp1.

View Alternative Names

SIR2, Tb927.7.1690, SIR2rp1, NAD-dependent protein deacetylase SIR2rp1, Regulatory protein SIR2 homolog 1, SIR2-related protein 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Trypanosoma brucei

Applications

WB, ICC

applications

Immunogen

Synthetic Peptide within Trypanosoma brucei brucei TREU927 SIR2rp1. The exact immunogen used to generate this antibody is proprietary information.

Q57V41

Specificity

ab106169 reacts specifically with the 38 kDa protein of Trypanosoma brucei

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Trypanosoma brucei": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purity
Whole antiserum
Purification notes
Lyophilized from 200 µl of serum.
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SIR2 protein also known as Silent mating type Information Regulation 2 homolog and sometimes called SIRT1 in humans serves as an NAD-dependent deacetylase. It weighs about 120 kDa and is expressed in various tissues including the brain heart and liver. Mechanically SIR2 removes acetyl groups from lysine residues on histones and other proteins influencing chromatin structure and gene expression. Its deacetylase activity plays a role in numerous cellular processes like DNA repair transcription and cell survival.
Biological function summary

SIR2 influences processes related to aging and metabolic regulation. It functions as a core component of the sirtuin protein family and associates with a complex that involves other sirtuins like SIRT2 and SIRT3. This protein alters the acetylation status of histones and non-histone proteins impacting cellular aging and stress resistance. By regulating mitochondrial biogenesis and oxidative stress responses SIR2 has critical roles in metabolic homeostasis and lifespan extension in model organisms.

Pathways

SIR2 participates actively in metabolic and stress-response pathways. It plays a significant role in the NAD+ salvage pathway and is implicated in the insulin/IGF-1 signaling pathway. SIR2 modulates the activity of several key proteins including the transcription factors FOXO and p53. FOXO proteins regulated by SIR2 deacetylation mediate the oxidative stress response and affect glucose metabolism. Interaction with p53 results in modulation of cell cycle arrest and apoptosis demonstrating SIR2’s influence beyond metabolism.

SIR2 has links to metabolic disorders and neurodegenerative diseases. Research shows associations between SIR2 activity and conditions like type 2 diabetes and Alzheimer’s disease. In the context of diabetes SIR2 impacts insulin sensitivity and glucose metabolism influencing the disease’s progression. In Alzheimer’s disease SIR2 interacts with APP the amyloid precursor protein affecting amyloid-beta production and neuronal survival. Understanding SIR2’s roles in these disorders could provide insights into potential therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.
See full target information SIR2rp1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Zoological research 46:1108-1120 PubMed41017397

2025

CircSHOC2 regulates steroid hormone synthesis in ovarian granulosa cells through the mir-130b-5p/ASH1L pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lu-Tong Zhang,Teng Zhang,Xiang-Rong Song,Madaniyati Mie-Lie,Yi-Hao Li,Lei Gao,Gong-She Yang,Gui-Yan Chu
View all publications
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Product promise

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