Anti-SIRT4 antibody

Target data

Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed : 16959573, PubMed : 17715127, PubMed : 24052263, PubMed : 25525879). Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications (PubMed : 24052263, PubMed : 25525879). Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed : 25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity (PubMed : 16959573, PubMed : 17715127). Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1 : expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed : 16959573, PubMed : 17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed : 23663782). Acts as a tumor suppressor (PubMed : 23562301, PubMed : 23663782). Also acts as a NAD-dependent protein deacetylase : mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed : 23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation (PubMed : 24043310). Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed : 24043310). Down-regulates insulin secretion (PubMed : 17715127).