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Rabbit Polyclonal SIVA antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Apoptosis regulatory protein Siva aa 1-150.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (AB224595), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (AB224595), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Apoptosis regulatory protein Siva aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link O15304

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/20.00000 - 1/200.00000

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Alternative names

Recommended products

Rabbit Polyclonal SIVA antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Apoptosis regulatory protein Siva aa 1-150.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Apoptosis regulatory protein Siva aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link O15304
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SIVA also known as CD27-binding protein SIVA is a pro-apoptotic protein involved in cell death mechanisms. This protein typically weighs around 15 kDa and predominantly locates in the cytoplasm and the nucleus of cells. It expresses in a variety of tissues including immune system organs like the thymus and spleen reflecting its integral role in immune function and development.

Biological function summary

SIVA impacts apoptosis regulation through its interaction with signaling pathways that mediate cell death. It binds to the CD27 receptor a member of the tumor necrosis factor receptor (TNFR) family which is critical for the induction of apoptosis. SIVA is known to interact with other proteins such as those in the Bcl-2 family which further emphasize its role in orchestrating cell death programs.

Pathways

Various apoptotic cascades involve SIVA notably the extrinsic apoptotic signaling pathway linked to the TNFR family. This pathway engages the FasL/Fas and TNFR1 complexes where SIVA functions alongside other apoptosis regulators like caspases. SIVA also interfaces with proteins like TRAFs (tumor necrosis factor receptor-associated factors) which modulate signaling pathways related to immune responses and cell survival.

Associated diseases and disorders

Research links SIVA to cancer and autoimmune conditions. In cancer SIVA’s modulation of apoptosis can influence tumor progression and chemotherapy resistance often through its interaction with Bcl-2 proteins that inhibit cell death. Similarly in autoimmune diseases where immune cell regulation is disrupted SIVA's role affects T-cell survival and overall immune responses connecting it with disorders where TNFR family signaling plays a part.

Product promise

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (ab224595), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (ab224595)

    Paraffin-embedded human small intestine tissue stained for SIVA using ab224595 at 1/100 dilution in immunohistochemical analysis.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (ab224595), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (ab224595)

    Paraffin-embedded human testis tissue stained for SIVA using ab224595 at 1/100 dilution in immunohistochemical analysis.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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