AB224595

Anti-SIVA antibody

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Rabbit Polyclonal SIVA antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SIVA1 aa 1-150.

View Alternative Names

SIVA, SIVA1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (AB224595)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (AB224595)

Paraffin-embedded human small intestine tissue stained for SIVA using ab224595 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIVA antibody (AB224595)

Paraffin-embedded human testis tissue stained for SIVA using ab224595 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SIVA1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O15304

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SIVA also known as CD27-binding protein SIVA is a pro-apoptotic protein involved in cell death mechanisms. This protein typically weighs around 15 kDa and predominantly locates in the cytoplasm and the nucleus of cells. It expresses in a variety of tissues including immune system organs like the thymus and spleen reflecting its integral role in immune function and development.

Biological function summary

SIVA impacts apoptosis regulation through its interaction with signaling pathways that mediate cell death. It binds to the CD27 receptor a member of the tumor necrosis factor receptor (TNFR) family which is critical for the induction of apoptosis. SIVA is known to interact with other proteins such as those in the Bcl-2 family which further emphasize its role in orchestrating cell death programs.

Pathways

Various apoptotic cascades involve SIVA notably the extrinsic apoptotic signaling pathway linked to the TNFR family. This pathway engages the FasL/Fas and TNFR1 complexes where SIVA functions alongside other apoptosis regulators like caspases. SIVA also interfaces with proteins like TRAFs (tumor necrosis factor receptor-associated factors) which modulate signaling pathways related to immune responses and cell survival.

Research links SIVA to cancer and autoimmune conditions. In cancer SIVA’s modulation of apoptosis can influence tumor progression and chemotherapy resistance often through its interaction with Bcl-2 proteins that inhibit cell death. Similarly in autoimmune diseases where immune cell regulation is disrupted SIVA's role affects T-cell survival and overall immune responses connecting it with disorders where TNFR family signaling plays a part.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

See full target information SIVA1

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

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