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BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Rabbit Polyclonal SKI antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SKI conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 2.5 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.
Ski oncogene, Proto-oncogene c-Ski, SKI
Rabbit Polyclonal SKI antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SKI conjugated to Keyhole Limpet Haemocyanin.
Ski oncogene, Proto-oncogene c-Ski, SKI
IgG
Rabbit
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
SKI functions as a negative regulator of the TGF-beta/Smad signaling pathway. It interacts within transcriptional complexes modulating gene transcription through direct binding to SMAD proteins which are intracellular mediators of TGF-beta signals. This binding capability enables SKI to influence the transcription of TGF-beta-inducible genes impacting cell growth and differentiation processes.
SKI also known by names such as SLOAN-KETTERING INDERTERMINATE PROTEIN plays a role as a transcriptional co-repressor that affects gene expression. It has a molecular mass of approximately 84 kDa. SKI primarily exhibits expression in tissues like the colon brain and skeletal muscle. This expression pattern suggests its involvement in regulating diverse biological processes in these tissues.
The involvement of SKI in the TGF-beta signaling cascade is significant. This pathway has important roles in cellular proliferation differentiation and apoptosis. SKI counters the activity of other proteins within this pathway such as SMAD2 and SMAD3 by altering their ability to regulate gene expression. This interaction highlights SKI's part in controlling cellular responses initiated by TGF-beta signals.
SKI's connection to cancer and its progression is noteworthy especially in conditions like leukemia and colorectal cancer. Aberrant SKI expression links to the disruption of normal TGF-beta signaling a condition associated with unchecked cellular proliferation. In leukemia for instance altered SKI activity can interact with the MYC oncogene further influencing cell cycle regulation and promoting malignant transformation.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab115553, at 2.5µg/ml, staining SKI in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
ab115553, at 2.5µg/ml, staining SKI in Formalin-fixed, Paraffin-embedded Human Pancreas tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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