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AB134837

Anti-SLC10A2/ASBT antibody

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(1 Publication)

Goat Polyclonal SLC10A2/ASBT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC10A2 aa 300 to C-terminus.

View Alternative Names

ASBT, ISBT, NTCP2, SLC10A2, Ileal sodium/bile acid cotransporter, Apical sodium-dependent bile acid transporter, Ileal Na(+)/bile acid cotransporter, Ileal sodium-dependent bile acid transporter, Na(+)-dependent ileal bile acid transporter, Solute carrier family 10 member 2, IBAT

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A2/ASBT antibody (AB134837)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A2/ASBT antibody (AB134837)

Immunohistochemistry analysis of formalin fixed, paraffin embedded Human small intestine tissue labelling SLC10A2/ASBT with ab134837 at 3.75 μg/ml.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC10A2 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q12908

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SLC10A2 also known as the apical sodium-dependent bile acid transporter (ASBT) functions as a sodium/bile acid symporter. It facilitates the uptake of bile acids from the intestinal lumen into enterocytes. SLC10A2 has a mass of about 48 kDa and is highly expressed in the ileal section of the small intestine. This transporter is important in the enterohepatic circulation of bile acids. By importing bile acids SLC10A2 aids in maintaining the bile acid pool and promotes fat digestion and absorption.
Biological function summary

SLC10A2 assists in the absorption and recycling of bile acids to help maintain liver function and lipid metabolism. Although not part of a larger protein complex it tightly works with other transporters to ensure efficient bile acid retrieval. The action of this transporter supports energy balance and nutrient absorption in the body providing a mechanistic link between nutrient availability and metabolic regulation.

Pathways

SLC10A2 plays an essential role in the enterohepatic circulation of bile acids. This pathway reconciles bile acid reabsorption in the intestine with their secretion by the liver. The transporter works in conjunction with other proteins like FXR (Farnesoid X Receptor) and NTCP (SLC10A1) in this pathway to regulate bile acid concentrations impacting cholesterol and lipid homeostasis.

Dysfunctions in SLC10A2 correlate with bile acid malabsorption which can lead to conditions such as chronic diarrhea and Crohn's disease. The Bile Acid Binding Protein (BABP) is related to SLC10A2 in these disorders as it helps solubilize bile acids in the intestinal cells. Proper functioning of SLC10A2 is essential to avoid these disorders and support normal gastrointestinal health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed : 7592981, PubMed : 9458785, PubMed : 9856990). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed : 7592981, PubMed : 9458785, PubMed : 9856990). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed : 33222321).
See full target information SLC10A2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal 37:10290-10309 PubMed28931573

2017

Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Toru Doi,Toru Ogata,Junji Yamauchi,Yasuhiro Sawada,Sakae Tanaka,Motoshi Nagao
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Product promise

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