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Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (AB224438), expandable thumbnail
  • Western blot - Anti-SLC10A3 antibody (AB224438), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SLC10A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link P09131

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PWB
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info
1/1000.00000 - 1/2500.00000
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Tested
Tested

Species

Human

Dilution info
0.04000-0.40000 µg/mL
Notes

-

Target data

Function

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Alternative names

Recommended products

Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human SLC10A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link P09131
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SLC10A3 commonly known as the sodium/bile acid cotransporter family member 3 is a protein with approximately 50 kDa mass. It functions as a transporter in cell membranes participating in the movement of molecules across membranes. Its primary structure suggests a role related to solute transport sharing features with other members of the solute carrier family. Researchers have detected SLC10A3 expression in a variety of human tissues including the kidney liver and placenta indicating its importance in multiple physiological processes.

Biological function summary

The activity of SLC10A3 contributes to cellular uptake and release of specific substrates although its exact substrates are not fully characterized. It may function independently but its physiological roles suggest it could also engage within larger protein complexes facilitating multidirectional transport. The presence of SLC10A3 in vital organs supports its involvement in essential metabolic pathways helping to maintain cellular homeostasis and proper function of metabolic tissues.

Pathways

SLC10A3 engages in transport processes that influence key biochemical pathways such as bile acid metabolism and cholesterol homeostasis. It shares relationships with proteins like other solute carrier family members which collectively impact these pathways. Modulation within these pathways often alters the intracellular balance of ions and metabolites having downstream effects on cellular and organismal health.

Associated diseases and disorders

Altered SLC10A3 function associates with conditions like cholestasis and certain metabolic disorders. Dysregulation of this transporter can influence bile acid concentration and cholesterol levels impacting liver function and systemic metabolic balance. It connects with closely related proteins involved in similar transport functions such as SLC10A1 implicating a broader relevance in liver health and disease progression. Understanding these links improves insights into treatment and diagnostics for diseases related to transport dysfunctions.

Product promise

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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (ab224438), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (ab224438)

    Paraffin-embedded human urinary bladder tissue stained for SLC10A3 using ab224438 at 1/1000 dilution in immunohistochemical analysis.

  • Western blot - Anti-SLC10A3 antibody (ab224438), expandable thumbnail

    Western blot - Anti-SLC10A3 antibody (ab224438)

    All lanes: Western blot - Anti-SLC10A3 antibody (ab224438) at 1/100 dilution

    All lanes: RT4 (human urinary bladder cancer cell line) cell lysate

    Predicted band size: 50 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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