Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SLC10A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link P09131
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Target data
Function
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
Alternative names
DXS253E, P3, SLC10A3, P3 protein, Solute carrier family 10 member 3
Recommended products
Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SLC10A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information. Database link P09131
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC10A3 commonly known as the sodium/bile acid cotransporter family member 3 is a protein with approximately 50 kDa mass. It functions as a transporter in cell membranes participating in the movement of molecules across membranes. Its primary structure suggests a role related to solute transport sharing features with other members of the solute carrier family. Researchers have detected SLC10A3 expression in a variety of human tissues including the kidney liver and placenta indicating its importance in multiple physiological processes.
- Biological function summary
The activity of SLC10A3 contributes to cellular uptake and release of specific substrates although its exact substrates are not fully characterized. It may function independently but its physiological roles suggest it could also engage within larger protein complexes facilitating multidirectional transport. The presence of SLC10A3 in vital organs supports its involvement in essential metabolic pathways helping to maintain cellular homeostasis and proper function of metabolic tissues.
- Pathways
SLC10A3 engages in transport processes that influence key biochemical pathways such as bile acid metabolism and cholesterol homeostasis. It shares relationships with proteins like other solute carrier family members which collectively impact these pathways. Modulation within these pathways often alters the intracellular balance of ions and metabolites having downstream effects on cellular and organismal health.
- Associated diseases and disorders
Altered SLC10A3 function associates with conditions like cholestasis and certain metabolic disorders. Dysregulation of this transporter can influence bile acid concentration and cholesterol levels impacting liver function and systemic metabolic balance. It connects with closely related proteins involved in similar transport functions such as SLC10A1 implicating a broader relevance in liver health and disease progression. Understanding these links improves insights into treatment and diagnostics for diseases related to transport dysfunctions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (ab224438)
Paraffin-embedded human urinary bladder tissue stained for SLC10A3 using ab224438 at 1/1000 dilution in immunohistochemical analysis.
Western blot - Anti-SLC10A3 antibody (ab224438)
All lanes: Western blot - Anti-SLC10A3 antibody (ab224438) at 1/100 dilution
All lanes: RT4 (human urinary bladder cancer cell line) cell lysate
Predicted band size: 50 kDa
Downloads
Product protocols
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