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AB224438

Anti-SLC10A3 antibody

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(1 Publication)

Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.

View Alternative Names

DXS253E, P3, SLC10A3, P3 protein, Solute carrier family 10 member 3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (AB224438)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC10A3 antibody (AB224438)

Paraffin-embedded human urinary bladder tissue stained for SLC10A3 using ab224438 at 1/1000 dilution in immunohistochemical analysis.

Western blot - Anti-SLC10A3 antibody (AB224438)
  • WB

Supplier Data

Western blot - Anti-SLC10A3 antibody (AB224438)

All lanes:

Western blot - Anti-SLC10A3 antibody (ab224438) at 1/100 dilution

All lanes:

RT4 (human urinary bladder cancer cell line) cell lysate

Predicted band size: 50 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC10A3 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

P09131

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC10A3 commonly known as the sodium/bile acid cotransporter family member 3 is a protein with approximately 50 kDa mass. It functions as a transporter in cell membranes participating in the movement of molecules across membranes. Its primary structure suggests a role related to solute transport sharing features with other members of the solute carrier family. Researchers have detected SLC10A3 expression in a variety of human tissues including the kidney liver and placenta indicating its importance in multiple physiological processes.
Biological function summary

The activity of SLC10A3 contributes to cellular uptake and release of specific substrates although its exact substrates are not fully characterized. It may function independently but its physiological roles suggest it could also engage within larger protein complexes facilitating multidirectional transport. The presence of SLC10A3 in vital organs supports its involvement in essential metabolic pathways helping to maintain cellular homeostasis and proper function of metabolic tissues.

Pathways

SLC10A3 engages in transport processes that influence key biochemical pathways such as bile acid metabolism and cholesterol homeostasis. It shares relationships with proteins like other solute carrier family members which collectively impact these pathways. Modulation within these pathways often alters the intracellular balance of ions and metabolites having downstream effects on cellular and organismal health.

Altered SLC10A3 function associates with conditions like cholestasis and certain metabolic disorders. Dysregulation of this transporter can influence bile acid concentration and cholesterol levels impacting liver function and systemic metabolic balance. It connects with closely related proteins involved in similar transport functions such as SLC10A1 implicating a broader relevance in liver health and disease progression. Understanding these links improves insights into treatment and diagnostics for diseases related to transport dysfunctions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
See full target information SLC10A3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:20430 PubMed37993584

2023

NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Naixue Wang,Dantong Zhu,Yao Liu,Jingran Wu,Meiling Wang,Shanxiu Jin,Fangwei Fu,Baolei Li,Hongjuan Ji,Cheng Du,Zhendong Zheng
View all publications
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