Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | WB | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
DXS253E, P3, SLC10A3, P3 protein, Solute carrier family 10 member 3
Rabbit Polyclonal SLC10A3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC10A3 aa 50-250.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
SLC10A3 commonly known as the sodium/bile acid cotransporter family member 3 is a protein with approximately 50 kDa mass. It functions as a transporter in cell membranes participating in the movement of molecules across membranes. Its primary structure suggests a role related to solute transport sharing features with other members of the solute carrier family. Researchers have detected SLC10A3 expression in a variety of human tissues including the kidney liver and placenta indicating its importance in multiple physiological processes.
The activity of SLC10A3 contributes to cellular uptake and release of specific substrates although its exact substrates are not fully characterized. It may function independently but its physiological roles suggest it could also engage within larger protein complexes facilitating multidirectional transport. The presence of SLC10A3 in vital organs supports its involvement in essential metabolic pathways helping to maintain cellular homeostasis and proper function of metabolic tissues.
SLC10A3 engages in transport processes that influence key biochemical pathways such as bile acid metabolism and cholesterol homeostasis. It shares relationships with proteins like other solute carrier family members which collectively impact these pathways. Modulation within these pathways often alters the intracellular balance of ions and metabolites having downstream effects on cellular and organismal health.
Altered SLC10A3 function associates with conditions like cholestasis and certain metabolic disorders. Dysregulation of this transporter can influence bile acid concentration and cholesterol levels impacting liver function and systemic metabolic balance. It connects with closely related proteins involved in similar transport functions such as SLC10A1 implicating a broader relevance in liver health and disease progression. Understanding these links improves insights into treatment and diagnostics for diseases related to transport dysfunctions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Paraffin-embedded human urinary bladder tissue stained for SLC10A3 using ab224438 at 1/1000 dilution in immunohistochemical analysis.
All lanes: Western blot - Anti-SLC10A3 antibody (ab224438) at 1/100 dilution
All lanes: RT4 (human urinary bladder cancer cell line) cell lysate
Predicted band size: 50 kDa
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