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AB103295

Anti-SLC14A1/UTE antibody

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(2 Publications)

Rabbit Polyclonal SLC14A1/UTE antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC14A1.

View Alternative Names

HUT11, JK, RACH1, UT1, UTE, SLC14A1, Urea transporter 1, Solute carrier family 14 member 1

2 Images
Western blot - Anti-SLC14A1/UTE antibody (AB103295)
  • WB

Unknown

Western blot - Anti-SLC14A1/UTE antibody (AB103295)

All lanes:

Western blot - Anti-SLC14A1/UTE antibody (ab103295) at 1/500 dilution

All lanes:

Mouse liver tissue lysate at 50 µg

Predicted band size: 43 kDa

false

Western blot - Anti-SLC14A1/UTE antibody (AB103295)
  • WB

Unknown

Western blot - Anti-SLC14A1/UTE antibody (AB103295)

All lanes:

Western blot - Anti-SLC14A1/UTE antibody (ab103295) at 1/500 dilution

Lane 1:

SLC14A1/UTE transfected 293T cell line at 25 µg

Lane 2:

non transfected 293T cell line at 25 µg

Predicted band size: 28 kDa,30 kDa,32 kDa,34 kDa,35 kDa,354 kDa,36 kDa,39 kDa,42 kDa,43 kDa,45 kDa

Observed band size: 32 kDa,33 kDa,34 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SLC14A1.

Q13336

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC14A1 also known as UTE is a protein that functions as a urea transporter. It facilitates the movement of urea across cell membranes specifically in the kidney and erythrocytes. It has a molecular weight of approximately 50 kDa. The expression of SLC14A1 is notable in the renal medulla and red blood cells where it plays a role in maintaining the body's urea balance. This transporter contributes to urine concentration and detoxification processes by efficiently regulating urea levels within different tissues and body fluids.
Biological function summary

The function of SLC14A1 in transporting urea is important for nitrogen waste removal. It operates within renal epithelial cells to assist with the reabsorption of urea from urine back into the bloodstream contributing to water conservation and nitrogen excretion. SLC14A1 is not known to be part of a larger protein complex but interacts with other renal transporters to enhance its role in concentrating urine. This transport activity helps in creating the osmotic gradient necessary for the kidney's urine concentrating mechanism.

Pathways

SLC14A1 integrates into the renal system's water and urea reabsorption processes. It is pivotal in the urea cycle and the renal concentrating mechanism pathways. Its functionality is closely linked with aquaporin channels which are responsible for water reabsorption in the kidney. These pathways coordinate to regulate body fluid and electrolyte balance establishing a direct relationship between SLC14A1 and aquaporins to optimize urea transport and water reabsorption throughout the physiological system.

SLC14A1's impaired function is linked to urea transport dysfunctions such as urinary concentrating deficiency which can lead to conditions like nephrogenic diabetes insipidus. Defects or mutations in its gene can disrupt its transporter activity and affect the body's ability to concentrate urine leading to polyuria and dehydration. In certain scenarios altered activity of SLC14A1 might also interact with conditions related to anemia where urea transport in erythrocytes plays a role in maintaining red blood cell function and stability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed : 10514515, PubMed : 7797558, PubMed : 7989337, PubMed : 8997401). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
See full target information SLC14A1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 43:208 PubMed39061061

2024

SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yixun Zhang,Yumeng Yang,Xuan Qi,Peng Cui,Yi Kang,Haiyi Liu,Zhigang Wei,Haibo Wang

Frontiers in neuroanatomy 11:22 PubMed28424594

2017

Overexpression of Human SOD1 Leads to Discrete Defects in the Cerebellar Architecture in the Mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Pegah Afshar,Niloufar Ashtari,Xiaodan Jiao,Maryam Rahimi-Balaei,Xiaosha Zhang,Behzad Yaganeh,Marc R Del Bigio,Jiming Kong,Hassan Marzban
View all publications
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Product promise

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