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AB95365

Anti-SLC14A2 antibody

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(1 Review)

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(2 Publications)

Rabbit Polyclonal SLC14A2 antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Rat Slc14a2 aa 900 to C-terminus.

View Alternative Names

Ut2, Slc14a2, Urea transporter 2, Solute carrier family 14 member 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC14A2 antibody (AB95365)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC14A2 antibody (AB95365)

Immunohistochemical analysis of paraffin-embedded formalin fixed (4%) rat kidney tissue labelling SLC14A2 with ab95365 at 1/25 dilution for 1 hour at RT, followed by secondary antibody Goat Anti-Rabbit IgG (Alexa Fluor 488) (Green). Membrane staining on rat kidney tissue is observed. Counter stained with Actin-binding Phalloidin-Alexa Fluor 633; DAPI (blue) nuclear stain. (A) DAPI (blue) nuclear stain. (B) Phalloidin Alex Fluor 633 (Red) F-Actin stain. (C) UT-A1 Antibody (D) Composite image.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Rat Slc14a2 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q62668

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p>1 μg/ml of ab95365 was sufficient for detection of SLC14A2 in 20μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC14A2 also known as urea transporter B (UT-B) functions as a urea transporter protein. Its mass is approximately 102 kDa. SLC14A2 is expressed in several tissues with high levels found in the kidneys bladder and red blood cells. The protein facilitates the reabsorption of urea in the renal medulla playing an essential role in the urinary concentrating mechanism.
Biological function summary

SLC14A2 contributes to the regulation of urea transport across cell membranes to maintain nitrogen balance. It does not function as part of a larger protein complex but works in conjunction with other transporters to modulate urea concentrations. This process is vital in organisms that require efficient excretion of nitrogen products such as mammals.

Pathways

SLC14A2 functions within the renal medullar urea recycling and excretion pathway. It acts together with aquaporins particularly AQP1 and AQP3 to regulate water reabsorption and enhance urinary concentration. Additionally SLC14A2 plays a part in the urea cycle linking it to nitrogen metabolism pathways that involve enzymes such as carbamoyl phosphate synthetase 1.

Mutations or dysfunctions in SLC14A2 can lead to nephrogenic diabetes insipidus due to impaired water reabsorption. This condition relates to defects in the urinary concentrating ability of the kidneys often connected to altered aquaporin function. Changes in SLC14A2 activity have also been associated with disorders of electrolyte imbalance impacting proteins involved in transport regulation like SLC26A4.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.. Isoform 2. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.. Isoform 3. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.. Isoform 4. Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism.
See full target information Slc14a2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry and biophysics reports 43:102140 PubMed40688491

2025

Development of a novel anti-human glypican 5 monoclonal antibody (GMab-1) for multiple applications.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Kaneko,Tomohiro Tanaka,Shiori Fujisawa,Guanjie Li,Hiroyuki Satofuka,Mika K Kaneko,Hiroyuki Suzuki,Yukinari Kato

Journal of the American Society of Nephrology : JA 31:1212-1225 PubMed32381599

2020

Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney.

Applications

Unspecified application

Species

Unspecified reactive species

Ann M Laszczyk,Atsuko Y Higashi,Sanjeevkumar R Patel,Craig N Johnson,Abdul Soofi,Saji Abraham,Gregory R Dressler
View all publications
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Product promise

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