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AB203043

Anti-SLC15A1/PEPT1 antibody

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(5 Publications)

Rabbit Polyclonal SLC15A1/PEPT1 antibody. Suitable for Flow Cyt, IHC-P, ICC/IF and reacts with Human, Mouse, Rat, Chicken, Cow samples. Cited in 5 publications.

View Alternative Names

PEPT1, SLC15A1, Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Peptide transporter 1

2 Images
Flow Cytometry - Anti-SLC15A1/PEPT1 antibody (AB203043)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-SLC15A1/PEPT1 antibody (AB203043)

Flow cytometry analysis of HCCLM3 cells labelling SLC15A1/PEPT1 (green) with ab203043 at dilution of 1/100 followed by incubation with a conjugated secondary antibody. The controls are as follows, control cells (blue), secondary only (light blue) and isotype control (orange).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC15A1/PEPT1 antibody (AB203043)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC15A1/PEPT1 antibody (AB203043)

Immunohistochemical analysis of formalin-fixed and paraffin embedded human kidney tissue sections labeling SLC15A1/PEPT1 with ab203043 at 1/200 followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Cow, Mouse, Rat, Chicken

Applications

ICC/IF, Flow Cyt, IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/20 - 1/100", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/500", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Chicken": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Cow": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC15A1 also known as PEPT1 is a protein that functions as a proton-coupled oligopeptide transporter. It facilitates the uptake of di- and tripeptides from the intestinal lumen which is essential for nutrient absorption and peptide-based drug delivery. The molecular weight of PEPT1 is approximately 78 kDa. The expression of PEPT1 is mainly in the brush border membrane of small intestine epithelial cells playing a significant role in the digestive system's initial phase of protein digestion.
Biological function summary

PEPT1 mediates the cellular uptake of nutrient peptides and peptidomimetic drugs. PEPT1 functions as a transporter that is not part of a larger protein complex but interacts closely with various solute carrier proteins. Its activity helps regulate amino acid availability within the intestinal cells influencing local metabolic pathways and systemic amino acid levels.

Pathways

PEPT1 is integrally involved in the protein digestion and absorption pathway influencing the systemic availability of dietary peptides and drugs. This protein also connects with other transporters such as SLC15A2 (PEPT2) in related pathways to manage di- and tripeptide absorption and reabsorption. Together these transporters ensure efficient nutrient acquisition and influence pharmacokinetics for orally administered peptide-based medications.

Dysregulation of PEPT1 expression or function associates with conditions such as inflammatory bowel disease (IBD) and malabsorption syndromes. Variants in the SLC15A1 gene might affect PEPT1 altering its transport efficiency and contributing to these gastrointestinal disorders. Additionally changes in PEPT1 activity could influence the bioavailability of peptide-based drugs affecting therapeutic outcomes for diseases requiring such treatments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1 : 1 or 2 : 1 (By similarity) (PubMed : 15521010, PubMed : 18367661, PubMed : 19685173, PubMed : 26320580, PubMed : 7896779, PubMed : 8914574, PubMed : 9835627). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed : 15521010, PubMed : 9835627).
See full target information SLC15A1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7937 PubMed40858611

2025

scIVNL-seq resolves in vivo single-cell RNA dynamics of immune cells during Salmonella infection.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Xiong,Runyuan Wu,Yuanxin Wang,Yuwei Xu,Cunzhen Li,Deyuan Kong,Ziqi Xiao,Peikang Zhang,Zhonglong Wang,Peng Zhang,Ying Du,Hui Guo,Pingping Zhu,Shunmin He,Zusen Fan

Microbiome 11:148 PubMed37408039

2023

Mechanism of inulin in colic and gut microbiota of captive Asian elephant.

Applications

Unspecified application

Species

Unspecified reactive species

Tingbei Bo,He Liu,Min Liu,Qiyong Liu,Qingduo Li,Yipeng Cong,Yi Luo,Yuqi Wang,Bo Yu,Tianchun Pu,Lu Wang,Zheng Wang,Dehua Wang

Nature methods 19:1449-1460 PubMed36280722

2022

Geometric engineering of organoid culture for enhanced organogenesis in a dish.

Applications

Unspecified application

Species

Unspecified reactive species

Sunghee Estelle Park,Shawn Kang,Jungwook Paek,Andrei Georgescu,Jeehan Chang,Alex Yoon Yi,Benjamin J Wilkins,Tatiana A Karakasheva,Kathryn E Hamilton,Dan Dongeun Huh

Aging 13:13859-13875 PubMed34029211

2021

Curcumin inhibits the proliferation and migration of vascular smooth muscle cells by targeting the chemerin / CMKLR1 / LCN2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yaqiong He,Rongning Wang,Peng Zhang,Jianlong Yan,Nan Gong,Yuhang Li,Shaohong Dong

Frontiers in veterinary science 7:570593 PubMed33240950

2020

Effects of Probiotics BaSC06 on Intestinal Digestion and Absorption, Antioxidant Capacity, Microbiota Composition, and Macrophage Polarization in Pigs for Fattening.

Applications

Unspecified application

Species

Unspecified reactive species

Xuefang Cao,Li Tang,Zihan Zeng,Baikui Wang,Yuanhao Zhou,Qi Wang,Peng Zou,Weifen Li
View all publications
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