Rabbit Polyclonal SLC15A1/PEPT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications.
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- Cell stem cell 29:101-115.e102021SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Gu,Hua Wang,Xiaofeng Huang,Judith Kraiczy,Pratik N P Singh,Charles Ng,Sezin Dagdeviren,Sean Houghton,Oscar Pellon-Cardenas,Ying Lan,Yaohui Nie,Jiaoyue Zhang,Kushal K Banerjee,Emily J Onufer,Brad W Warner,Jason Spence,Ellen Scherl,Shahin Rafii,Richard T Lee,Michael P Verzi,David Redmond,Randy Longman,Kristian Helin,Ramesh A Shivdasani,Qiao ZhouPubMed 34582804
- Cell death & disease 12:5322021Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization.Applications:WBReactive species:HumanYanhong Wang,Jiaqi Wang,Lingrong Yang,Liqing Qiu,Yuhui Hua,Shixiu Wu,Su Zeng,Lushan Yu,Xiaoli ZhengPubMed 34031358
- Journal of animal physiology and animal nutrition 103:1610-16182019Effects of methionine partially replaced by methionyl-methionine dipeptide on intestinal function in methionine-deficient pregnant mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiong Chen,Caihong Wang,Feng-Qi Zhao,Jianxin Liu,Hongyun LiuPubMed 31106911
- Journal of animal science and biotechnology 9:72018Functional characterization of oligopeptide transporter 1 of dairy cows.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQingbiao Xu et. al.PubMed 29387385
- Oncology letters 14:4158-41662017Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-a novel strategy for tumor-targeted therapy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanxia Gong,Jie Zhang,Xiang Wu,Tao Wang,Jia Zhao,Zhi Yao,Qingyu Zhang,Xi Liu,Xu JianPubMed 28943923
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
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Target data
Function
Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity) (PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580, PubMed:7896779, PubMed:8914574, PubMed:9835627). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:15521010, PubMed:9835627).
Alternative names
PEPT1, SLC15A1, Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Peptide transporter 1
Recommended products
Rabbit Polyclonal SLC15A1/PEPT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC15A1 also known as PEPT1 is a protein that functions as a proton-coupled oligopeptide transporter. It facilitates the uptake of di- and tripeptides from the intestinal lumen which is essential for nutrient absorption and peptide-based drug delivery. The molecular weight of PEPT1 is approximately 78 kDa. The expression of PEPT1 is mainly in the brush border membrane of small intestine epithelial cells playing a significant role in the digestive system's initial phase of protein digestion.
- Biological function summary
PEPT1 mediates the cellular uptake of nutrient peptides and peptidomimetic drugs. PEPT1 functions as a transporter that is not part of a larger protein complex but interacts closely with various solute carrier proteins. Its activity helps regulate amino acid availability within the intestinal cells influencing local metabolic pathways and systemic amino acid levels.
- Pathways
PEPT1 is integrally involved in the protein digestion and absorption pathway influencing the systemic availability of dietary peptides and drugs. This protein also connects with other transporters such as SLC15A2 (PEPT2) in related pathways to manage di- and tripeptide absorption and reabsorption. Together these transporters ensure efficient nutrient acquisition and influence pharmacokinetics for orally administered peptide-based medications.
- Associated diseases and disorders
Dysregulation of PEPT1 expression or function associates with conditions such as inflammatory bowel disease (IBD) and malabsorption syndromes. Variants in the SLC15A1 gene might affect PEPT1 altering its transport efficiency and contributing to these gastrointestinal disorders. Additionally changes in PEPT1 activity could influence the bioavailability of peptide-based drugs affecting therapeutic outcomes for diseases requiring such treatments.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC15A1/PEPT1 antibody (ab78020)
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human brain cerebellum tissue using 10µg/ml Anti-RAMP3 antibody ab78017.
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