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AB150877

Anti-SLC15A5 antibody

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Rabbit Polyclonal SLC15A5 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC15A5 aa 500 to C-terminus.

View Alternative Names

Solute carrier family 15 member 5, SLC15A5

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC15A5 antibody (AB150877)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC15A5 antibody (AB150877)

Immunohistochemical analysis of Paraffin-embedded Human stomach tissue labeling SLC15A5 with ab150877 at 1/50 dilution.

Western blot - Anti-SLC15A5 antibody (AB150877)
  • WB

Unknown

Western blot - Anti-SLC15A5 antibody (AB150877)

All lanes:

Western blot - Anti-SLC15A5 antibody (ab150877) at 1/100 dilution

Lane 1:

RT4 lysate

Lane 2:

U 251 MG lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 65 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC15A5 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

A6NIM6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50.00000 - 1/200.00000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100.00000 - 1/200.00000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SLC15A5 protein also known as Solute Carrier Family 15 Member 5 functions as a proton-coupled oligopeptide transporter. This protein facilitates the translocation of small peptides across cellular membranes. SLC15A5 exhibits a molecular mass of approximately 72 kDa. The transporter is widely expressed in human tissues including the brain and kidneys with significant activity in neurons and renal epithelial cells.
Biological function summary

The transporter SLC15A5 mediates the uptake of di- and tripeptides from the extracellular environment influencing cellular nutritional and metabolic processes. The activity of SLC15A5 plays a critical role in peptide homeostasis. Although SLC15A5 does not seem to be part of a larger protein complex directly its operation impacts the physiological environment significantly interacting functionally with several intracellular pathways.

Pathways

Oligopeptide transport involving SLC15A5 integrates into broader cellular systems such as the nitrogen metabolism and nutrient absorption pathways. These pathways include critical interactions with amino acid transport systems and neurotransmitter regulators. Proteins related through these pathways include SLC15A1 and SLC15A2 which share similar transport functions and coordinate with SLC15A5 to maintain efficient peptide cycling and nutrient availability in the cells.

Research has linked SLC15A5 expression to neurological conditions and renal disorders. Anomalies in SLC15A5 function or expression levels may contribute to the development of psychiatric disorders such as schizophrenia. Additionally connections have been drawn between SLC15A5 and renal dysfunctions given its renal expression and transport role. Other transporter proteins like SLC15A1 can serve as compensatory mechanisms when SLC15A5 malfunctions although only partially providing limited amelioration of disease impacts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton oligopeptide cotransporter.
See full target information SLC15A5
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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