Anti-SLC16A9 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The SLC16A9 gene encodes a protein known as a monocarboxylate transporter 9 (MCT9). MCT9 belongs to the solute carrier family 16 and facilitates the transport of monocarboxylates such as lactate and pyruvate across cellular membranes. The protein has a molecular weight of approximately 57 kDa. Expression of MCT9 is found primarily in the kidney liver and to a lesser extent in the brain. It functions to maintain cellular homeostasis by enabling cells to excrete excess metabolic byproducts.

Biological function summary

The interaction of MCT9 with solutes plays a role in maintaining acid-base balance in cells. MCT9 is incorporated into the larger family of proton-coupled transporters which are important for pH regulation within the body. The efficient transport of monocarboxylates is important for energy metabolism enabling tissues to process waste during high metabolic demands. As a member of the MCT family MCT9 operates independently rather than forming complexes which distinguishes its mechanism of action from some other transporters.

Pathways

The activity of MCT9 integrates into the lactic acid cycle and glucose metabolism pathways. The protein's function to transport lactate is especially relevant to the Cori cycle where lactate produced in muscles is transported to the liver for gluconeogenesis. MCT9 activity links with other transporters like MCT1 and MCT4 which also manage lactate shuttling contributing to the cellular energetic needs and metabolic waste handling.

Associated diseases and disorders

The impaired function of MCT9 has associations with renal tubular acidosis and gout. These conditions arise when a dysfunctional transporter leads to inadequate excretion or re-absorption of organic acids disturbing the body's acid-base balance. In the context of gout MCT9 interacts potentially with uric acid transporters like URAT1 influencing uric acid levels and linking MCT9 to the disease pathology. Understanding these associations helps in characterizing MCT9 as a potential therapeutic target in the treatment of related disorders.