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AB151751

Anti-SLC17A1 antibody [EPR9614]

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(1 Publication)

Rabbit Recombinant Monoclonal SLC17A1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

NPT1, SLC17A1, Sodium-dependent phosphate transport protein 1, Na(+)/PI cotransporter 1, Na/Pi-4, Renal Na(+)-dependent phosphate cotransporter 1, Renal sodium-dependent phosphate transport protein 1, Sodium/phosphate cotransporter 1, Solute carrier family 17 member 1, Renal sodium-phosphate transport protein 1

1 Images
Western blot - Anti-SLC17A1 antibody [EPR9614] (AB151751)
  • WB

Unknown

Western blot - Anti-SLC17A1 antibody [EPR9614] (AB151751)

All lanes:

Western blot - Anti-SLC17A1 antibody [EPR9614] (ab151751) at 1/1000 dilution

All lanes:

Human fetal kidney lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP

Predicted band size: 51 kDa

false

  • Carrier free

    Anti-SLC17A1 antibody [EPR9614] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9614

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC17A1 also known as NPT1 or sodium-dependent phosphate transport protein 1 is a protein that functions primarily as a transporter. It facilitates the reabsorption of phosphate ions in the renal proximal tubules. This protein has a molecular mass of approximately 54 kDa and is mainly expressed in the kidney. The presence of SLC17A1 in renal tissues plays an important role in maintaining plasma phosphate levels which is essential for bone health and various metabolic processes. Additionally SLC17A1 belongs to the solute carrier family 17 acting as an important mediator in phosphate homeostasis.
Biological function summary

This transporter plays a significant role in the regulation of phosphate balance in the body. By functioning in the renal system SLC17A1 affects phosphate excretion and reabsorption which directly influences mineral and bone metabolism. It operates as part of a greater network involving other phosphate transporters and channels in the kidney. This network ensures that the body maintains proper phosphate levels necessary for critical cellular functions and skeletal integrity. The efficient operation of SLC17A1 in this context is essential to the homeostatic maintenance of serum phosphate concentrations.

Pathways

SLC17A1 is an important component of phosphate homeostasis and mineral metabolism pathways. It interacts with other proteins such as SLC34A1 another sodium-dependent phosphate transporter and plays a part in the renal tubular reabsorption of phosphate. These pathways are vital in regulating the levels of phosphate which is integral for energy production nucleotide synthesis and signaling processes in cells. The transporter collaborates with other elements in the parathyroid hormone-related pathways impacting overall calcium homeostasis and bone remodeling.

SLC17A1 is closely linked to conditions such as phosphate wasting disorders and renal tubular reabsorption abnormalities. Mutations or dysfunctions in the SLC17A1 gene may lead to diseases like hypophosphatemia characterized by low serum phosphate levels and associated bone disorders such as rickets and osteomalacia. The protein's involvement in these conditions often overlaps with interactions alongside other transport proteins like SLC20A1 affecting phosphate absorption and systemic phosphate balance. Understanding this relationship is important for developing therapeutic strategies aimed at treating phosphate-related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Important for the resorption of phosphate by the kidney (PubMed : 7826357). May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed : 7826357). Plays a role in urate transport in the kidney (PubMed : 25252215, PubMed : 27906618).
See full target information SLC17A1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PLoS genetics 16:e1009176 PubMed33137164

2020

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Emily M Schleicher,Ashna Dhoonmoon,Lindsey M Jackson,Kristen E Clements,Coryn L Stump,Claudia M Nicolae,George-Lucian Moldovan
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com