Rabbit Polyclonal SLC22A13 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:31780526, PubMed:35144162, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:31780526, PubMed:35144162). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).
OCTL1, ORCTL3, SLC22A13, OCTL1, ORCTL3, Solute carrier family 22 member 13, Organic anion transporter 10, Organic cation transporter-like 3, OAT10, ORCTL-3, ORCTL3
Rabbit Polyclonal SLC22A13 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
SLC22A13 also known as organic cation transporter 13 or OAT10 functions as a transporter primarily involved in the movement of organic anions and cations across cell membranes. This transporter belongs to the SLC22 family and has a molecular mass of approximately 57 kDa. Researchers have found high expression of SLC22A13 in tissues like the kidney brain and placenta. The protein facilitates the exchange of substrates often linked to drug disposition influencing the body's response to pharmaceuticals.
The transport protein moves various small molecules such as certain metabolites and drugs across epithelial barriers. SLC22A13 does not operate in isolation; it interacts with other members of the SLC22 family which modulate the handling of drugs and endogenous compounds. This interaction forms part of a complex system that ensures the proper extrusion or uptake of these molecules maintaining cellular and systemic homeostasis.
The transporter plays a significant role in the renal reabsorption and excretion pathways. It is well integrated into the pathways controlling the biotransformation and clearance of toxins and drugs such as the organic anion transporter's role in drug metabolism. SLC22A13 is related to other proteins like SLC22A6 and SLC22A8 within these pathways which together contribute to maintaining the balance of organic anions and cations in the body.
Alterations in SLC22A13 have shown links to certain metabolic disorders including gout and certain neurodegenerative diseases. The protein's activity can influence urate levels potentially contributing to gout development. Furthermore researchers have noted interactions between SLC22A13 and proteins like SLC2A9 highlighting its role in conditions involving urate transport dysfunction. These relationships highlight the protein's contribution to disease states providing potential targets for therapeutic intervention.
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Paraffin-embedded human kidney tissue stained for SLC22A13 using ab224498 at 1/50 dilution in immunohistochemical analysis.
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