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Rabbit Polyclonal SLC22A13 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A13 antibody - C-terminal (AB224498), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y226

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

1/50.00000 - 1/200.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target data

Function

Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:31780526, PubMed:35144162, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:31780526, PubMed:35144162). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable).

Alternative names

Recommended products

Rabbit Polyclonal SLC22A13 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Solute carrier family 22 member 13 aa 500-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y226
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SLC22A13 also known as organic cation transporter 13 or OAT10 functions as a transporter primarily involved in the movement of organic anions and cations across cell membranes. This transporter belongs to the SLC22 family and has a molecular mass of approximately 57 kDa. Researchers have found high expression of SLC22A13 in tissues like the kidney brain and placenta. The protein facilitates the exchange of substrates often linked to drug disposition influencing the body's response to pharmaceuticals.

Biological function summary

The transport protein moves various small molecules such as certain metabolites and drugs across epithelial barriers. SLC22A13 does not operate in isolation; it interacts with other members of the SLC22 family which modulate the handling of drugs and endogenous compounds. This interaction forms part of a complex system that ensures the proper extrusion or uptake of these molecules maintaining cellular and systemic homeostasis.

Pathways

The transporter plays a significant role in the renal reabsorption and excretion pathways. It is well integrated into the pathways controlling the biotransformation and clearance of toxins and drugs such as the organic anion transporter's role in drug metabolism. SLC22A13 is related to other proteins like SLC22A6 and SLC22A8 within these pathways which together contribute to maintaining the balance of organic anions and cations in the body.

Associated diseases and disorders

Alterations in SLC22A13 have shown links to certain metabolic disorders including gout and certain neurodegenerative diseases. The protein's activity can influence urate levels potentially contributing to gout development. Furthermore researchers have noted interactions between SLC22A13 and proteins like SLC2A9 highlighting its role in conditions involving urate transport dysfunction. These relationships highlight the protein's contribution to disease states providing potential targets for therapeutic intervention.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A13 antibody - C-terminal (ab224498), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A13 antibody - C-terminal (ab224498)

    Paraffin-embedded human kidney tissue stained for SLC22A13 using ab224498 at 1/50 dilution in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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