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AB235004

Anti-SLC22A23 antibody

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(1 Publication)

Rabbit Polyclonal SLC22A23 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC22A23 aa 1-250.

View Alternative Names

C6orf85, SLC22A23, Solute carrier family 22 member 23

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A23 antibody (AB235004)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A23 antibody (AB235004)

Paraffin-embedded human small intestine tissue stained for SLC22A23 using ab235004 at 1/200 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. Staining was performed on a Leica BondTM system. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC22A23 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

A1A5C7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC22A23 also known as OCTN-R1 is a member of the solute carrier family 22. This protein weighs around 61 kDa and facilitates the transport of organic cations. It operates by transferring small molecules across cellular membranes. SLC22A23 shows expression in a variety of tissues including the liver kidneys and brain suggesting a wide functional role within the human body.
Biological function summary

SLC22A23 impacts cellular homeostasis and detoxification processes by managing the cellular intake and expulsion of endogenous and exogenous molecules. Currently there is limited evidence that it forms part of a larger protein complex; however its solute transport function highlights its role in maintaining cellular balance and protecting cells from harmful compounds. It supports essential biological processes by interfacing with other transport proteins within the cell.

Pathways

SLC22A23 participates in the organic cation transport pathway which is essential for xenobiotic metabolism. This pathway includes key interactions with other transporters such as SLC22A1 and SLC22A2 which similarly manage the movement of organic cations. Another pathway that involves SLC22A23 is related to drug metabolism wherein it assists in mediating the clearance of pharmaceutical compounds.

SLC22A23 has been connected to renal dysfunction and certain neurodegenerative diseases due to its pivotal role in solute transportation. Aberrations in its function can lead to improper detoxification contributing to renal impairment. Additionally the protein's expression in the brain suggests a possible link to neurodegenerative issues with interactions involving proteins like SLC22A4 which has implications for similar disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information SLC22A23
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental dermatology 31:1253-1263 PubMed35514241

2022

Silencing of Rab23 by siRNA inhibits ultraviolet B-induced melanogenesis via downregulation of PKA/CREB/MITF.

Applications

Unspecified application

Species

Unspecified reactive species

Xuanjin Wei,Min Huang,Yi Yang,Yali Liu,Sumin Chi,Chengxin Li
View all publications
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Product promise

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