Rabbit Polyclonal SLC22A6 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC22A6.
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- Renal failure 44:513-5242022Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChen Feiteng,Chen Lei,Li Deng,Xu Chaoliang,Xu Zijie,Shao Yi,Sha MingleiPubMed 35311469
- Molecules (Basel, Switzerland) 25:2020Nano Ellagic Acid Counteracts Cisplatin-Induced Upregulation in OAT1 and OAT3: A Possible Nephroprotection Mechanism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesThikryat Neamatallah,Nagla El-Shitany,Aymn Abbas,Basma G Eid,Steve Harakeh,Soad Ali,Shaker MousaPubMed 32630784
- Journal of ethnopharmacology 261:1130542020Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLe Kang et. al.PubMed 32534113
- Life sciences 224:41-502019Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Zhou et. al.PubMed 30902543
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 111:162-1682018The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSiwei Wang,Yuejuan Fang,Xinfen Yu,Lu Guo,Xiaoxi Zhang,Daozong XiaPubMed 30579255
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLC22A6. The exact immunogen used to generate this antibody is proprietary information. Database link Q4U2R8
Reactivity data
Select an application| IHC-P | |
|---|---|
| Rat | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 0.50000-1.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
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Target data
Function
Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:11669456, PubMed:11907186, PubMed:14675047, PubMed:22108572, PubMed:23832370, PubMed:28534121, PubMed:9950961). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (PubMed:9887087). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:11907186). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:26377792). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:22108572, PubMed:23832370). May transport glutamate (PubMed:26377792). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:11669456, PubMed:14675047). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate (PubMed:14675047, PubMed:26377792). Xenobiotics include the mycotoxin ochratoxin (OTA) (PubMed:11669456). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (PubMed:35307651).
Alternative names
OAT1, PAHT, SLC22A6, Solute carrier family 22 member 6, Organic anion transporter 1, PAH transporter, Renal organic anion transporter 1, hOAT1, hPAHT, hROAT1
Recommended products
Rabbit Polyclonal SLC22A6 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC22A6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLC22A6. The exact immunogen used to generate this antibody is proprietary information. Database link Q4U2R8
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The SLC22A6 protein also known as organic anion transporter 1 (OAT1) functions mechanically as a transporter that facilitates the movement of organic anions across cell membranes. The protein has a molecular mass of about 56 kDa. Expression of SLC22A6 occurs in various tissues with significant levels in the kidneys where it is found in the basolateral membrane of the renal proximal tubules. This expression profile highlights its key role in renal function particularly in the excretion and detoxification processes.
- Biological function summary
SLC22A6 plays a role in the renal secretion of endogenous substances and drugs. It is part of the organic anion transporter family and participates in the elimination of molecules such as prostaglandins urate and multiple pharmaceutical agents. By functioning in concert with other transporter proteins SLC22A6 influences the pharmacokinetics of drugs and the clearance of metabolic waste products. Its activity ensures the proper balance of organic anions contributing to homeostasis.
- Pathways
SLC22A6 integrates into the metabolic and excretory pathways in the kidney. It is part of the metabolic detoxification process capturing drugs and metabolites for renal excretion. The transporter works in a network that includes proteins such as SLC22A8 and urate-anion exchanger (URAT1) ensuring efficient substance clearance. In drug metabolism SLC22A6 interaction determines drug disposition with implications for drug efficacy and toxicity.
- Associated diseases and disorders
Researchers have identified SLC22A6 as significantly involved in the pathogenesis of chronic kidney disease (CKD) and hypertension. Variation or malfunction in this transporter can affect the renal excretion of toxic metabolites and drugs contributing to CKD progression. Additionally altered function of SLC22A6 influences blood pressure regulation linking it to hypertension. These associations highlight the importance of SLC22A6 as a therapeutic target in treating renal and cardiovascular disorders.
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Tested
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Expected
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Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC22A6 antibody (ab131087)
Immunohistochemical analysis of paraffin embedded Rat kidney tissue labelling SLC22A6 with ab131087 at 0.5 µg/ml.
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